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Recent Advances in Protein Kinase CK2, a Potential Therapeutic Target in Cancer

Abstract

Casein kinase 2 (CK2) is a type of conserved serine/ threonine protein kinase that phosphorylates many important proteins in the eukaryotes. There are various research revealing the importance of CK2 in cellular process and cancer. It is abnormally elevated in all most all kinds of cancer hence considered one of the major factors in aggressiveness of cancer cells. This is majorly caused due to the CK2 dependent phosphorylation of various of key proteins that are linked to apoptosis. As a result, CK2 has been emerged as a promising target in the treatment of cancer and many therapeutic inhibitors has been discovered and developed. Indeed, of all these developments these inhibitors lack selectivity, cell permeability, metabolic stability and correct pharmacokinetic characteristics, which results in less therapeutic effect in cancer cells. Hence, versatile biological nano carriers should be developed, with the abilities of targeted delivery of developed therapeutic compounds. In brief the current review focuses on the normal functions and role of CK2 in cancer, further we have also described the various therapeutic inhibitors developed for CK2 inhibition with its future perspectives as a therapeutic target.

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Nipun, V.B., Amin, K.A. Recent Advances in Protein Kinase CK2, a Potential Therapeutic Target in Cancer. Russ J Bioorg Chem 48, 919–931 (2022). https://doi.org/10.1134/S1068162022050144

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Keywords:

  • casein kinase 2 (CK2)
  • inhibitors
  • cancer
  • apoptosis
  • targeted delivery
  • nanoparticles