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Synthesis of Isatin-Based Oxo-Spiro Chromene Schiff’s Bases as Antibacterial and Anticancer Agents

Abstract

Herein, we report series of isatin-based oxo-spiro chromene Schiff’s bases, synthesized by condensing 2,7-diamino-2'-oxospiro[chromene-4,3'-indoline]-3-carbonitrile with aromatic aldehydes using efficient acid catalyst, silica sulfuric acid (SSA). Spectroscopic techniques have corroborated the formation of desired products. Derivatives were screened in vitro for antibacterial and anticancer activities. Molecular docking was also performed to predict the possible mode of action of these derivatives.

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ACKNOWLEDGMENTS

The authors are thankful to Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) Kharghar, Navi Mumbai for anticancer screening, Dr. Prafulla Choudhari from Bharati Vidyapeeth College of Pharmacy, Kolhapur for Antibacterial studies.

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Correspondence to S. N. Dandekar or S. V. Rathod.

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This article does not contain any studies involving animals performed by any of the authors. This article does not contain any studies involving human participants performed by any of the authors.

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Dandekar, S.N., Lotlikar, O.A., Ramana, M.M. et al. Synthesis of Isatin-Based Oxo-Spiro Chromene Schiff’s Bases as Antibacterial and Anticancer Agents. Russ J Bioorg Chem 48, 1053–1058 (2022). https://doi.org/10.1134/S1068162022050089

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  • DOI: https://doi.org/10.1134/S1068162022050089

Keywords:

  • oxo-spiro chromene
  • Schiff’s base
  • antibacterial
  • anticancer
  • molecular docking