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Discovery of New Quinazoline-Based Anticancer Agents as VEGFR-2 Inhibitors and Apoptosis Inducers

Abstract

Novel quinazoline compounds have been designed and synthesized aiming to discover new anticancer agents. Additional study was carried out on the most powerful derivatives, (Xb). A cell cycle research indicated that (Xb) mostly stops the cell cycle in the G2/M phase. The Annexin V-FITC apoptosis assay revealed that (Xb) increased apoptosis when compared with the control. It also demonstrated decreased anti-apoptotic Bcl-2 protein expression and increased BAX and caspases 3 expression levels.

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ACKNOWLEDGMENTS

The authors are thankful to Taif University Researchers Supporting Project number (TURSP-2020/123), Taif University, Taif, Saudi Arabia, for their assistance.

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Correspondence to M. F. Ahmed.

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“This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the author.

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Ahmed, M.F., Khalifa, A.S. & Eed, E.M. Discovery of New Quinazoline-Based Anticancer Agents as VEGFR-2 Inhibitors and Apoptosis Inducers. Russ J Bioorg Chem 48, 739–748 (2022). https://doi.org/10.1134/S1068162022040033

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  • DOI: https://doi.org/10.1134/S1068162022040033

Keywords:

  • quinazoline
  • isatin
  • antitumor
  • caspases 3
  • cell cycle
  • apoptosis