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Synthesis and Biological Evaluation of Some Novel N-Alkyl/Aryl-1-Nitro-10H-Phenothiazine-3-Sulfonamide Derivatives

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Abstract

A series of new derivatives of N-alkyl/aryl-1-nitro-10H-phenothiazine-3-sulfonamides were developed and synthesized by 1-nitro-10H-phenothiazine-3-sulfonyl chloride with various amines. The intermediates 1-nitro-10H-phenothiazine-3-potassium sulfonate and 1-nitro -10H-phenothiazine-3-sulfonyl chlorides were synthesized by well known methods. The newly synthesized compounds were evaluated for their antioxidant and antibacterial activity, and 1-nitro-N-(thiophen-2-ylmethyl)-10H-phenothiazine-3-sulfonamide, N-(2-chlorophenyl)-1-nitro-10H-phenothiazine-3-sulfonamide and N-cyclohexyl-1-nitro-10H-phenothiazine-3-sulfonamide were found to exhibit good to excellent activity compared to standard drugs.

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ACKNOWLEDGMENTS

The authors are thankful to the Principal and Management of C.K.M. Arts and Science College for encouragement and thanks to the Head, Department of Biotechnology, University College, Kakatiya University and Warangal for the data on biological activity provided.

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Authors and Affiliations

  1. CKM Arts and Science College, Warangal, Telangana, 506006, India

    Vasudha Mallam & Baru Vijaya Kumar

  2. Department of Physical Sciences/Chemistry, Kakatiya Institute of Technology and Science (Autonomous), Warangal, Telangana, 506015, India

    M. Ranadheer Kumar

Authors
  1. Vasudha Mallam
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  2. M. Ranadheer Kumar
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Correspondence to Baru Vijaya Kumar.

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This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the author.

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Vasudha Mallam, Kumar, M.R. & Kumar, B.V. Synthesis and Biological Evaluation of Some Novel N-Alkyl/Aryl-1-Nitro-10H-Phenothiazine-3-Sulfonamide Derivatives. Russ J Bioorg Chem 47, 1288–1292 (2021). https://doi.org/10.1134/S1068162021060170

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