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Cu(I)-Promoted Regioselective Synthesis of Some New Benzimidazole-1,2,3-Triazole Frameworks as In Vitro Anticancer Agents

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Abstract

The regioselective synthesis of twelve new benzimidazole-1,2,3-triazole hybrids through the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between 1-(3-azidopropyl)-1H-benzo[d]imidazole and several terminal alkynes was described herein. All the synthesized compounds were further evaluated for their in vitro anticancer activity against three human cancer cell lines like PC3, A549, and MCF-7 using etoposide as standard drug. Four compounds named by 1-(3-(4-(3,5-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl)propyl)-1H-benzo[d]imidazole,1-(3-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)propyl)-1H benzo[d]imidazole,4-(1-(3-(1H-benzo[d]imidazol-1-yl)propyl)-1H-1,2,3-triazol-4-yl) benzonitrile and 1-(3-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1H-benzo[d]imidazole were displayed promising activity, in those the compound was shown outstanding activity against PC3, A549, and MCF-7 with IC50 values of 3.01, 3.82, and 2.91 μM respectively.

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Authors and Affiliations

  1. Chemistry Services, GVK Biosciences Pvt. Ltd, IDA, TS 500076, Nacharam, Hyderabad, India

    Manmohan Reddy Depa, Suneetha Potla, Umesh C. Narkhede & Vinod D. Jadhav

  2. Department of Organic Chemistry, Food, Drugs and Water, Andhra University, Visakhapatnam, Andhra Pradesh, India

    Manmohan Reddy Depa, Suneetha Potla, Vinod D. Jadhav & Siddaiah Vidavalur

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  1. Manmohan Reddy Depa
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  2. Suneetha Potla
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  4. Vinod D. Jadhav
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  5. Siddaiah Vidavalur
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Correspondence to Vinod D. Jadhav.

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Manmohan Reddy Depa, Potla, S., Narkhede, U.C. et al. Cu(I)-Promoted Regioselective Synthesis of Some New Benzimidazole-1,2,3-Triazole Frameworks as In Vitro Anticancer Agents. Russ J Bioorg Chem 47, 1028–1033 (2021). https://doi.org/10.1134/S1068162021050228

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