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Solvent-Free Synthesis, Characterization, and In Vitro Biological Activity Study of Xanthenediones and Acridinediones

Abstract

The present work highlights the broad range of oxygen and nitrogen heterocycles and their applications in medicinal field. A facial approach has been developed for the synthesis of coumarinyl xanthenes and acridine derivatives via one pot multicomponent reaction using green chemical technique. All the isolated compounds were characterized by spectral analysis such as IR NMR and mass. Compounds were screened for their antibacterial and anti-inflammatory activity. While, biological activity results of synthesized coumarin derivatives are quite significant and contribute to the medicinal chemistry.

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ACKNOWLEDGMENTS

The author acknowledges UGC-UPE, RGNF fellowship and UGC-DSA for Departmental financial support to carry the research work. The author Jyoti M. Madar also thanks NMR Research Center, Indian Institute of Science (IISC), Bangalore and University Sophisticated Instrumentation Center, Karnatak University, Dharwad (USIC) for the spectral analysis.

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Correspondence to Lokesh A. Shastri.

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This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the author.

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Madar, J.M., Samundeeswari, S., Holiyachi, M. et al. Solvent-Free Synthesis, Characterization, and In Vitro Biological Activity Study of Xanthenediones and Acridinediones. Russ J Bioorg Chem 47, 535–542 (2021). https://doi.org/10.1134/S1068162021020163

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Keywords:

  • Acriflavine
  • proflavine
  • 9-aminoacridine and 9-arylxanthene
  • silica-supported tungstic acid (STA)