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Solvent-Free Synthesis, Characterization, and In Vitro Biological Activity Study of Xanthenediones and Acridinediones

Russian Journal of Bioorganic Chemistry volume 47, pages 535–542 (2021)Cite this article

Abstract

The present work highlights the broad range of oxygen and nitrogen heterocycles and their applications in medicinal field. A facial approach has been developed for the synthesis of coumarinyl xanthenes and acridine derivatives via one pot multicomponent reaction using green chemical technique. All the isolated compounds were characterized by spectral analysis such as IR NMR and mass. Compounds were screened for their antibacterial and anti-inflammatory activity. While, biological activity results of synthesized coumarin derivatives are quite significant and contribute to the medicinal chemistry.

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ACKNOWLEDGMENTS

The author acknowledges UGC-UPE, RGNF fellowship and UGC-DSA for Departmental financial support to carry the research work. The author Jyoti M. Madar also thanks NMR Research Center, Indian Institute of Science (IISC), Bangalore and University Sophisticated Instrumentation Center, Karnatak University, Dharwad (USIC) for the spectral analysis.

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Authors and Affiliations

  1. Department of Chemistry, Karnatak University, 580003, Karnataka, Dharwad, India

    Jyoti M. Madar, S. Samundeeswari, Megharaja Holiyachi, Nirmala S. Naik, Varsha Pawar, Parashuram Gudimani & Lokesh A. Shastri

  2. MarathaMandals Central Research Laboratory, 590010, Karnataka, Belagavi, India

    Vijay M. Kumbar

  3. Department of Chemistry, G.S.S. College, 590006, Karnataka, Belagavi, India

    Vinay A. Sunagar

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  1. Jyoti M. Madar
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  2. S. Samundeeswari
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  3. Megharaja Holiyachi
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  5. Varsha Pawar
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  6. Parashuram Gudimani
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Correspondence to Lokesh A. Shastri.

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Madar, J.M., Samundeeswari, S., Holiyachi, M. et al. Solvent-Free Synthesis, Characterization, and In Vitro Biological Activity Study of Xanthenediones and Acridinediones. Russ J Bioorg Chem 47, 535–542 (2021). https://doi.org/10.1134/S1068162021020163

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  • DOI: https://doi.org/10.1134/S1068162021020163

Keywords:

  • Acriflavine
  • proflavine
  • 9-aminoacridine and 9-arylxanthene
  • silica-supported tungstic acid (STA)