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Synthesis, Characterization, and Evaluation of Antibacterial Activity of New Bis-Dapsone-Derived Dihydropyridines Using Fe3O4@SiO2–Pr@L-proline

Abstract

Fe3O4@SiO2–Pr@L-proline magnetic nanoparticles were synthesized and their efficiency as nanocatalyst for the synthesis of new derivatives of bis dapsone derived dihydropyridines via one-pot three-component condensation reaction of various aromatic aldehydes, dimedone and dapsone in aqueous media was investigated. The products were characterized by 1H NMR, 13C NMR, FT-IR and CHNS analysis. These bis-drugs present high antibacterial activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with halogen or hydroxyl functional groups.

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Financial support from the Research Council of Rasht BranchPayame Noor University, is sincerely acknowledged.

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Correspondence to Leila Zare Fekri.

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This article doesnot contain any studies involving human participants performed by any of the authors and doesnot contain any studies involving animals performed by any of the author.

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Fekri, L.Z., Zadeh, L.H. Synthesis, Characterization, and Evaluation of Antibacterial Activity of New Bis-Dapsone-Derived Dihydropyridines Using Fe3O4@SiO2–Pr@L-proline. Russ J Bioorg Chem 47, 584–592 (2021). https://doi.org/10.1134/S1068162021020126

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  • DOI: https://doi.org/10.1134/S1068162021020126

Keywords:

  • dapsone
  • dihydropyridines
  • antibacterial
  • Fe3O4@SiO2-pr@l-proline
  • three-component reaction