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Synthesis and Acaricidal Activity of Aryl-Spirobutyrolactone Derivatives against Spider Mites under Greenhouse and Field Conditions

Russian Journal of Bioorganic Chemistry volume 47, pages 221–229 (2021)Cite this article

Abstract

Propesticides play an important role in modern agrochemicals research and development. In the controlling of harmful insects and mites in agriculture, propesticide strategy offers a unique and modern approach to acaricide development. In this study, a series of aryl-spirobutyrolactone pharmacophore based alkylated compounds were synthesized and characterized by 1H NMR and ESI-MS. All of this compounds exhibited excellent acaricidal activities against Tetranychus cinnabarinus at 2.5 mg/L in greenhouse test, and some of them showed better activity than spirodiclofen against eggs of T. cinnabarinus at 0.625 mg/L. In the field trials, compounds (Vc), (Ve) and (Vf) were evaluated against Panonychus ulmi and Panonychus citri at three different concentrations. The results showed that compounds (Ve) and (Vf) have the potential to develop into new proacaricide with further test and toxicity evaluation.

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ACKNOWLEDGMENTS

This work was supported by Collaboration Innovation Center of Zhejiang Green Pesticide.

Funding

This work was partly funded by the Key Research and Development Program of Zhejiang Province (no. 2019C02024).

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Authors and Affiliations

  1. College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, China

    L. K. Zhong, X. H. Liu & C. X. Tan

  2. Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, 310023, Hangzhou, China

    L. K. Zhong, J. Yuan & T. M. Xu

  3. School of Forestry and Biotechnology, Zhejiang A&F University, 311300, Hangzhou, China

    J. Yuan

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  1. L. K. Zhong
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  2. J. Yuan
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  3. X. H. Liu
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  4. T. M. Xu
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  5. C. X. Tan
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Corresponding authors

Correspondence to J. Yuan or C. X. Tan.

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This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the authors.

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The authors have declared that no conflict of interest exists.

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Zhong, L.K., Yuan, J., Liu, X.H. et al. Synthesis and Acaricidal Activity of Aryl-Spirobutyrolactone Derivatives against Spider Mites under Greenhouse and Field Conditions. Russ J Bioorg Chem 47, 221–229 (2021). https://doi.org/10.1134/S1068162021010295

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  • DOI: https://doi.org/10.1134/S1068162021010295

Keywords:

  • propesticide
  • proacaricide
  • aryl-spirobutyrolactone
  • mite
  • activity