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Antiradical and Antimicrobial Activity of Thiosemicarbaside and 1,2,4-Triazole Derivatives of Hydroxybenzoic Acid

Russian Journal of Bioorganic Chemistry volume 46, pages 537–541 (2020)Cite this article

Abstract

The antimicrobial and antioxidant activity of synthesized biologically active compounds have been evaluated in comparison with the standard antioxidant, ascorbic acid. The antioxidant activity of the compounds has been studied by their ability to interact with the 2,2-diphenyl-1-picrylhydrazyl radical (\({\text{DPP}}{{{\text{H}}}^{\centerdot }}\)). The proposed test system has revealed the pronounced antiradical activity of 2-(2-hydroxybenzoyl)-N-phenylhydrazinecarbothioamide (1) (IC50(DPPH) = 15.5 μM) and 2-(4-hydroxybenzoyl)N-phenylhydrazinecarbothiamide (2) (IC50(DPPH) = 31.7 μM). A weak antibacterial activity of these compounds has been shown against gram-positive and gram-negative test strains.

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Authors and Affiliations

  1. Buketov State University, 100028, Karaganda, Kazakhstan

    Zh. B. Satpaeva, S. D. Fazylov & M. Zh. Burkeev

  2. Institute of Organic Synthesis and Coal Chemistry, 100008, Karaganda, Kazakhstan

    Zh. B. Satpaeva, O. A. Nurkenov & S. D. Fazylov

  3. RSE National Center for Biotechnology, Ministry of Education and Science, 010000, Nur-Sultan, Kazakhstan

    Z. T. Shulgau

  4. Karaganda State Medical University, 100000, Karaganda, Kazakhstan

    S. B. Akhmetova

Authors
  1. Zh. B. Satpaeva
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  2. Z. T. Shulgau
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  3. S. B. Akhmetova
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  4. O. A. Nurkenov
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  5. S. D. Fazylov
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  6. M. Zh. Burkeev
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Correspondence to Zh. B. Satpaeva.

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Translated by A. Levina

Corresponding author: e-mail: satpaeva_zh@mail.ru.

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Satpaeva, Z.B., Shulgau, Z.T., Akhmetova, S.B. et al. Antiradical and Antimicrobial Activity of Thiosemicarbaside and 1,2,4-Triazole Derivatives of Hydroxybenzoic Acid. Russ J Bioorg Chem 46, 537–541 (2020). https://doi.org/10.1134/S1068162020040172

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  • DOI: https://doi.org/10.1134/S1068162020040172

Keywords:

  • antioxidant
  • antiradical
  • antimicrobial activity
  • strain
  • free radical
  • thiosemicarbazide
  • 1,2,4-triazole
  • DPPH