Abstract—
Molecular modeling, which identified several peptide sequences, was carried out in search for compounds capable of reducing the interleukin-8 concentration in human blood plasma. The replacement of the glutamic acid residue in the Glu-His-OMe and Glu-His-Trp-OMe compounds by its cyclic form, as well as the introduction of the DTyr and DAla residues into the sequence Asp-Tyr-Ala-Pro, was shown to double their ability to bind interleukin-8.
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Abbreviations: IL-8, interleukin 8; Boc, tert-butyloxycarbonyl; DCC, N,N'-dicyclohexylcarbodiimide; HOBt, N-hydroxybenzotriazole; Bzl, benzyl; TEA, triethylamine; Pfp, pentafluorophenyl; ESI, electrospray ionization.
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Gribovskaya, O.V., Martinovich, V.P., Makarevich, D.A. et al. Modification of Oligopeptides Increasing the Effectiveness of Their Interaction with Interleukin-8 in Human Blood Plasma. Russ J Bioorg Chem 46, 165–170 (2020). https://doi.org/10.1134/S1068162020020107
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DOI: https://doi.org/10.1134/S1068162020020107