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Modification of Oligopeptides Increasing the Effectiveness of Their Interaction with Interleukin-8 in Human Blood Plasma

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Abstract—

Molecular modeling, which identified several peptide sequences, was carried out in search for compounds capable of reducing the interleukin-8 concentration in human blood plasma. The replacement of the glutamic acid residue in the Glu-His-OMe and Glu-His-Trp-OMe compounds by its cyclic form, as well as the introduction of the DTyr and DAla residues into the sequence Asp-Tyr-Ala-Pro, was shown to double their ability to bind interleukin-8.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    O. V. Gribovskaya, V. P. Martinovich, D. A. Makarevich & V. P. Golubovich

  2. Belarus State Medical University, 220116, Minsk, Belarus

    T. V. Ryabtseva & V. V. Kirkovskiy

Authors
  1. O. V. Gribovskaya
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  2. V. P. Martinovich
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  3. D. A. Makarevich
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  4. V. P. Golubovich
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  5. T. V. Ryabtseva
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  6. V. V. Kirkovskiy
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Corresponding author

Correspondence to O. V. Gribovskaya.

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COMPLIANCE WITH ETHICAL STANDARDS

All applicable international, national, and/or institutional principles when working with people have been followed.

This article does not contain any studies involving animals as subjects of research.

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Authors declare no conflict of interest.

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Translated by I. Shipounova

Abbreviations: IL-8, interleukin 8; Boc, tert-butyloxycarbonyl; DCC, N,N'-dicyclohexylcarbodiimide; HOBt, N-hydroxybenzotriazole; Bzl, benzyl; TEA, triethylamine; Pfp, pentafluorophenyl; ESI, electrospray ionization.

Corresponding author: phone: +375-(17)2678263; e-mail: olymelnik@yandex.ru.

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Gribovskaya, O.V., Martinovich, V.P., Makarevich, D.A. et al. Modification of Oligopeptides Increasing the Effectiveness of Their Interaction with Interleukin-8 in Human Blood Plasma. Russ J Bioorg Chem 46, 165–170 (2020). https://doi.org/10.1134/S1068162020020107

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  • DOI: https://doi.org/10.1134/S1068162020020107

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