Abstract
The abuse of antibiotics in therapy has lead to the development of resistance in the target organisms. The failure of presented antibiotics to control infections makes it essential to discover option to presently available drugs. Quorum sensing (QS) is a used by many bacteria to regulate gene expression in accordance with population density through the use of signal molecules or autoinducers. The QS is used by Bacteria populations to communicate and coordinate their group interactions, which is applied by pathogens in infection processes. The QS pathways in bacteria are composed of several parts, including bacteria populations, signal molecules, protein activators and target genes. The pathogenicity in numerous bacteria is regulated by QS signaling systems. The QS inhibition system may cause the reduction of virulence and defense against bacterial infections. The QS is the main regulator of virulence and biofilm formation in Pseudomonas aeruginosa and other relevant bacteria. In P. aeruginosa, the expression of many virulence factors appears to be controlled by QS. So, according to the role of this mechanism in the regulation and production of many virulence factors, the function of QS is required for P. aeruginosa to cause disease and infection. In this article, we discussed the QS mechanism in gram-negative and gram-positive bacteria with a closer look at the P. aeruginosa. A variety of plants showed their effects on P. aeruginosa virulence. Extract of various plants control the regulatory QS genes and factors with marginal effects on bacterial growth. The quorum-quenching (QQ) mechanisms are unrelated to static or cidal effects. In fact, anti-QS have already shown promise in the battle against P. aeruginosa infections.
Similar content being viewed by others
REFERENCES
Centers for Disease Control and Prevention, H.I.P. National Nosocomial Infections Surveillance (NNIS) Report, data summary from January 1992–June 2004, issued October 2004: a report from the NNIS System, Am. J. Infection Control., 2004, vol. 32, pp. 470–485.
Manefield, M., Rasmussen, T.B., Henzter, M., Andersen, J.B., Steinberg, P., Kjelleberg, S., and Givskov, M., Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover, Microbiology, 2002, vol. 148, pp. 1119–1127.
Cumberbatch, A., Characterization of the Anti-Quorum Sensing Activity Exhibited by Marine Macroalgae of South Florida, Miami: Florida International University, Department of Biological Sciences, 2002.
Bjarnsholt, T., Jensen, P.O., Rasmussen, T.B., Christophersen, L., Calum, H., Hentzer, M.H., Hougen, P., Rygaard, J., Moser, C., Eberl, L., Hoiby, N., and Givskov, M., Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections, Microbiology, 2005, vol. 151, pp. 3873–3880.
Gao, M., Teplitski, M., Robinson, J.B., and Bauer, W.D., Production of substances by Medicago truncatula that affect bacterial quorum sensing, Mol. Plant Microbe Interact., 2003, vol. 16, pp. 827–834.
Yoon, Y. and Sofos, J.N., Absence of association of autoinducer-2-based quorum sensing with heat and acid resistance of Salmonella,J. Food Sci., 2010, vol. 75, pp. 444–448.
Adonizio, A.L.K., Downum, B.C., Bennett, and Mathee, K., Antiquorum sensing activity of medicinal plants in southern Florida, J. Ethnopharmacol., 2006, vol. 103, pp. 427–435.
Bauer, W.D. and Mathesius, U., Plant responses to bacterial quorum sensing signals, Curr. Opin. Plant Biol., 2004, vol. 7, pp. 429–433.
Carson, C.F., Riley, T.V., and Cookson, B.D., Efficacy and safety of tea tree oil as a topical antimicrobial agent, J. Hosp. Infect., 1998, vol. 40, pp. 175–178.
Carson, C.F. and Riley, T.V., Antimicrobial activity of the major components of the essential oil of Melaleuca alternifolia,J. Appl. Bacteriol., 1995, vol. 78, pp. 264–269.
Costerton, J.W., Lewandowski, Z., Caldwell, D.E., Korber, D.R., and Lappin-Scott, H.M., Microbial biofilms, Ann. Rev. Microbiol., 1995, vol. 49, pp. 711–745.
Bauer, W.D. and Tepletski, M., Can plants manipulate bacterial quorum sensing?, Aust. J. Plant Physiol., 2001, vol. 28, pp. 913–921.
Nealson, K.H., Platt, T., and Hastings, J.W., Cellular control of the synthesis and activity of the bacterial luminescent system, J. Bacteriol., 1970, vol. 104, pp. 313–322.
Hastings, J.W. and Greenberg, E.P., Quorum sensing: The explanation of a curious phenomenon reveals a common characteristic of bacteria, J. Bacteriol., 1999, vol. 181, pp. 2667–2668.
Schauder, S. and Bassler, B.L., The languages of bacteria, Genes Dev., 2001, vol. 15, pp. 1468–1480.
McClean, R.J.C., Pierson, I., Leland, S., and Fuqua, C., A simple screening protocol for the identification of quorum signal antagonists, J. Microbiol Methods, 2004, vol. 58, pp. 351–360.
Rasmussen, T.B., Manefield, M., Andersen, J.B., Eberl, L., Anthoni, U., Christophersen, C., Steinberg, P., Kjelleberg, S., and Givskov, M., How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1, Microbiology, 2000, vol. 146, pp. 3237–3244.
Henke, J.M. and Bassler, B.L., Bacterial social engagements, Trends Cell Biol., 2004, vol. 14, pp. 648–656.
Bassler, B.L., Wright, M., Showalter, R.E., and Silverman, M.R., Intercellular signalling in Vibrio harveyi: Sequence and function of genes regulating expression of luminescence, Mol. Microbiol., 1993, vol. 9, pp. 773–786.
Stevens, A. and Greenberg, E., Quorum sensing in Vibrio fischeri: Essential elements for activation of the luminescence genes, J. Bacteriol., 1997, vol. 179, pp. 557–562.
Fuqua, C. and Greenberg, E.P., Self perception in bacteria: Quorum sensing with acylated homoserine lactones, Curr. Opin. Microbiol., 1998, vol. 1, pp. 183–189.
Whitehead N.A., Barnard A.M., Slater H., Simpson N.J., Salmond G.P. Quorum-sensing in gram-negative bacteria, FEMS Microbiol. Rev., 2001, vol. 25, pp. 365–404.
Cao, M., Feng, Y., Wang, C., Zheng, F., Li, M., Liao, H., Mao, Y., Pan, X., Wang, J., Hu, D., Hu, F., Tang, J., Functional definition of LuxS, an autoinducer-2 (AI-2) synthase and its role in full virulence of Streptococcus suis serotype 2, J. Microbiol., 2011, vol. 49, pp. 1000–1011.
Halliday, N.M., Hardie, K.R., Williams, P., Winzer, K., and Barrett, D.A., Quantitative liquid chromatography-tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli,Anal. Biochem., 2010, vol. 403, pp. 1–2.
Hagen, S.J., Son, M., Weiss, J.T., and Young, J.H., Bacterium in a box: Sensing of quorum and environment by the LuxI/LuxR gene regulatory circuit, J. Biol. Phys., 2010, vol. 36, pp. 317–327.
Sperandio, V. and Sdi, A., Sensing of acyl-homoserine lactones by enterohemorrhagic E. coli (EHEC) serotype O157:H7 in the bovine rumen, Gut Microbes, 2010, vol. 1, pp. 432–435.
Pesci, E., Pearson, J., Seed, P., and Iglewski, B., Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa,J. Bacteriol., 1997, vol. 179, pp. 3127–3132.
Surette, M.G. and Bassler, B.L., Quorum sensing in Escherichia coli and Salmonella typhimurium,Proc. Natl. Acad. Sci. U. S. A., 1998, vol. 95, pp. 7046–7050.
Rodelas, B., Lithgow, J.K., Wisniewski-Dye, F., Hardman, A., Wilkinson, A., Economou, A., Williams, P., and Downie, J.A., Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae, J. Bacteriol., 1999, vol. 181, pp. 3816–3823.
Von Bodman, S.B., Bauer, W.D., and Coplin, D.L., Quorum sensing in plant-pathogenic bacteria, Ann. Rev. Phytopathol., 2003, vol. 41, pp. 455–482.
Fuqua, C. and Greenberg, E., Listening in on bacteria: Acyl-homoserine lactone signaling, Nat. Rev. Mol. Cell. Biol., 2002, vol. 3, pp. 685–695.
Fuqua, W.C., Winans, S.C., and Greenberg, E.P., Quorum sensing in bacteria: The LuxR–LuxI family of cell density-responsive transcriptional regulators, J. Bacteriol., 1994, vol. 176, pp. 269–275.
Dong, Y.H., Wang, L.H., Xu, J.L., Zhang, H.B., Zhang, X.F., and Zhang, L.H., Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase, Nature, 2001, vol. 411, pp. 813–817.
Cha, C.G.P., Chen, Y.C., Shaw, P.D., and Farrand, S.K., Production of acyl-homoserine lactone quorum-sensing signals by gram-negative plant-associated bacteria, Mol. Plant Microbe Interact., 1998, vol. 11, pp. 1119–1129.
Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, J. Clin. Invest., 2003, vol. 112, pp. 1460–1465.
Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum-sensing systems and virulence, Curr. Opin. Microbiol., 2003, vol. 6, pp. 56–60.
Debler, E.W., Kaufmann, G.F., Kirchdoerfer, R.N., Mee, J.M., Janda, K.D., and Wilson, I.A., Crystal structures of a quorum-quenching antibody, J. Mol. Biol., 2007, vol. 368, pp. 1392–1402.
Hoang, T.T., Sullivan, S.A., Cusick, J.K., and Schweizer, H.P., beta-Ketoacyl acyl carrier protein reductase (FabG) activity of the fatty acid biosynthetic pathway is a determining factor of 3-oxo-homoserine lactone acyl chain lengths, Microbiology, 2002, vol. 148, pp. 3849–3856.
Albus, A., Pesci, E., Runyen-Janecky, L., West, S., and Iglewski, B., Vfr controls quorum sensing in Pseudomonas aeruginosa,J. Bacteriol., 1997, vol. 179, pp. 3928–3935.
Dong, Y.H. and Zhang, L.H., Quorum sensing and quorum-quenching enzymes, J. Microbiol., 2005, vol. 43, pp. 101–109.
Schuster, M. and Greenberg, E.P., A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa,Int. J. Med. Microbiol., 2006, vol. 296, pp. 73–81.
Hentzer, M. and Givskov, M., Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, J. Clin. Invest., 2003, vol. 112, pp. 1300–1307.
Whitehead, N.A., Welch, M., and Salmond, G.P.C., Silencing the majority, Nat. Biotechnol., 2001, vol. 19, pp. 735–736.
Bodey, G.P., Bolivar, R., Fainstein, V., and Jadeja, L., Infections caused by Pseudomonas aeruginosa,Rev. Infect. Dis., 1983, vol. 5, pp. 279–313.
Vasil, M.L., Pseudomonas aeruginosa: Biology, mechanisms of virulence, epidemiology, J. Pediatrics, 1986, vol. 108, pp. 800–805.
Meyer, J., Neely, A., Stintzi, A., Georges, C., and Holder, I., Pyoverdin is essential for virulence of Pseudomonas aeruginosa,Infect. Immun., 1996, vol. 64, pp. 518–523.
Cox, C.D. and Adams, P., Siderophore activity of pyoverdin for Pseudomonas aeruginosa,Infect. Immun., 1985, vol. 48, pp. 130–138.
Choi, Y., Park, H.Y., Park, S.J., Kim, S.K., Ha, C., Im, S.J., and Lee, J.H., Erratum to: Growth phase-differential quorum sensing regulation of anthranilate metabolism in Pseudomonas aeruginosa,Mol. Cells, 2011, vol. 32, p. 597.
Kessler, E., Beta-lytic endopeptidases, Methods Enzymol., 1995, vol. 248, pp. 740–756.
Krcmery, V., Koprnova, J., Gogova, M., Grey, E., and Korcova, J., Pseudomonas aeruginosa bacteraemia in cancer patients, J. Infect., 2006, vol. 52, pp. 461–463.
Meynard J.L., Barbut F., Guiguet M., et al., Pseudomonas aeruginosa infection in human immunodeficiency virus infected patients. J. Infect., 1999, vol. 38, pp. 176–181.
Foca, M.D., Pseudomonas aeruginosa infections in the neonatal intensive care unit, Semin. Perinatol., 2002, vol. 26, pp. 332–339.
Robertson, D.M., Petroll, W.M., Jester, J.V., and Cavanagh, H.D., Current concepts: Contact lens related Pseudomonas keratitis, Contact Lens Anterior Eye, 2007, vol. 30, pp. 94–107.
Roland, P.S., Chronic suppurative otitis media: A clinical overview, Ear Nose Throat J., 2002, vol. 81, pp. 8–10.
Mowat, E., Paterson, S., Fothergill, J.L., Wright, E.A., Ledson, M.J., Walshaw, M.J., Brockhurst, M.A., Winstanley, C., Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections, Am. J. Respir. Crit. Care Med., 2011, vol. 183, pp. 1674–1679.
Shi, M., Li, Y., Wang, Y., Huang, J., Huang, X., and Xu, Y., Regulation of GacA on two phz gene clusters and quorum sensing in Pseudomonas sp. M18, Wei Sheng Wu Xue Bao, 2009, vol. 49, pp. 1306–1316.
Pustelny, C., Albers, A., Buldt-Karentzopoulos, K., Parschat, K., Chhabra, S.R., Camara, M., Williams, P., and Fetzner, S., Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa,Chem. Biol., 2009, vol. 16, pp. 1259–1267.
Cotar, A.I., Chifiriuc, M.C., Dinu, S., Pelinescu, D., Banu, O., and Lazar, V., Quantitative real-time PCR study of the influence of probiotic culture soluble fraction on the expression of Pseudomonas aeruginosa quorum sensing genes, Roum. Arch. Microbiol. Immunol., 2010, vol. 69, pp. 213–223.
Tsai, M.J., Teng, C.J., Teng, R.J., Lee, P.I., and Chang, M.H., Necrotizing bowel lesions complicated by Pseudomonas septicaemia in previously healthy infants, Eur J. Pediatrics, 1996, vol. 155, pp. 216–218.
Nicolle, L.E., Resistant pathogens in urinary tract infections, J. Am. Geriatrics Soc., 2002, vol. 50, pp. 230–235.
Sapico, F.L. and Montgomerie, J.Z., Vertebral osteomyelitis, Infect. Dis. Clin. North Am., 1990, vol. 4, pp. 539–550.
Yu, Y., Cheng, A.S., Wang, L., Dunne, W.M., and Bayliss, S.J., Hot tub folliculitis or hot hand-foot syndrome caused by Pseudomonas aeruginosa,J. Am. Acad. Dermatol., 2007, vol. 57, pp. 596–600.
Adonizio, A., Kong, K.F., and Pritt, K., Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by south Florida plant extracts, Antimicrob. Agents Chemother., 2008, vol. 52, pp. 198–203.
Hooper, D.C., Mode of action of fluoroquinolones, Drugs, 1999, vol. 58, pp. 6–10.
Flanders, S.A., Collard, H.R., and Saint, S., Nosocomial pneumonia: State of the science, Am. J. Infect. Control., 2006, vol. 34, pp. 84–93.
Donlan, R.M. and Costerton, J.W., Biofilms: Survival mechanisms of clinically relevant microorganisms, Clin. Microbiol. Rev., 2002, vol. 15, pp. 167–193.
Davies, D.G., Parsek, M.R., Pearson, J.P., Iglewski, B.H., Costerton, J.W., and Greenberg, E.P., The involvement of cell-to-cell signals in the development of a bacterial biofilm, Science, 1998, vol. 280, pp. 295–298.
Hoyle, B. and Costerton, J.W., Bacterial resistance to antibiotics: The role of biofilms, Progr. Drug Res., 1991, vol. 37, pp. 91–105.
Lyczak, J.B., Cannon, C.L., and Pier, G.B., Lung infections associated with cystic fibrosis, Clin. Microbiol. Rev., 2002, vol. 15, pp. 194–222.
Lazar, V. and Chifiriuc, M.C. Architecture and physiology of microbial biofilms, Roum. Arch. Microbiol. Immunol., 2010, vol. 69, pp. 95–107.
Martinez, L.R. and Fries, B.C., Fungal biofilms: Relevance in the setting of human disease, Curr. Fungal Infect. Rep., 2010, vol. 4, pp. 266–275.
Sintim, H.O., Smith, J.A., Wang, J., Nakayama, S., and Yan, L., Paradigm shift in discovering next-generation anti-infective agents: Targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules, Future Med. Chem., 2010, vol. 2, pp. 1005–1035.
Hentzer, M. and Givskov, M., Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, J. Clin. Invest., 2003, vol. 112, pp. 1300–1307.
Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, J. Clin. Invest., 2003, vol. 112, pp. 1460–1465.
McKnight, S.L., Iglewski, B.H., and Pesci, E.C., The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa.J. Bacteriol., 2000, vol. 182, pp. 2702–2708.
Espin, J.C., Garcia-Conesa, M.T., and Tomas-Barberan, F.A., Nutraceuticals: Facts and fiction, Phytochemistry, 2007, vol. 68, pp. 2986–3008.
Pesci, E.C., Milbank, J.B.J., Pearson, J.P., McKnight, S., Kende, A.S., Greenberg, E.P., and Iglewski, B.H., Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa,Proc. Natl. Acad. Sci. U. S. A., 1999, vol. 96, pp. 11 229–11 234.
Reimmann, C., Beyeler, M., Latifi, A., Winteler, H., Foglino, M., Lazdunski, A., and Haas, D., The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase, Mol. Microbiol., 1997, vol. 24, pp. 309–319.
Throup, J., Winson, M.K., Bainton, N.J., Bycroft, B.W., Williams, P., and Stewart, G.S.A.B., Signalling in bacteria beyond bioluminescence, in Bioluminescence and Chemiluminescence: Fundamentals and Applied Aspects, Campbell, A., Kricka, L., and Stanley, P., Eds., Chichester: Wiley, 1995.
Calfee, M.W., Coleman, J.P., and Pesci, E.C., Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa,Proc. Natl. Acad. Sci. U. S. A., 2001, vol. 98, pp. 11 633–11 637.
Holden, M.T.G., Chhabra, S.R., de Nys, R., Stead, P., Balnton, N.J., Hill, P.J., Manefield, M., Kumar, N., Maurice, L., England, D., Rice, S., Glvskov, M., Salmond, G.P.C., Stewart, G.S.A.B., Bycroft, B.W., Kjelleberg, S., and Williams, P., Quorum-sensing cross talk: Isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria, Mol. Microbiol., 1999, vol. 33, pp. 1254–1266.
Li, Q., Ni, H., Meng, S., He, Y., Yu, Z., and Li, L., Suppressing Erwinia carotovora pathogenicity by projecting N-acyl homoserine lactonase onto the surface of Pseudomonas putida cells, J. Microbiol. Biotechnol., 2011, vol. 21, pp. 1330–1335.
Van Delden, C. and Iglewski, B.H., Cell-to-cell signaling and Pseudomonas aeruginosa infections, Emerg. Infect. Dis., 1998, vol. 4, pp. 551–560.
Gambello, M.J. and Iglewski, B.H., Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression, J. Bacteriol., 1991, vol. 179, pp. 3000–3009.
Pritt, K., McPherson, C., and Ohman, D., Posttranslational control of the algT (algU)-encoded sigma22 for expression of the alginate regulon in Pseudomonas aeruginosa and localization of its antagonist proteins MucA and MucB (AlgN), J. Bacteriol., 1997, vol. 179, pp. 3711–3720.
Hentzer, M., Reidel, K., and Rasmussen, T.B., Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound, Microbiology, 2002, vol. 148, pp. 87–102.
Wu, H., Song, Z., Hentzer, M., Andersen, J.B., Molin, S., Givskov, M., and Hoiby, N., Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice, J. Antimicrob. Chemother., 2004, vol. 53, pp. 1054–1061.
Manefield, M., de Nys, R., Kumar, N., Read, R., Givskov, M., Steinberg, P., and Kjelleberg, S., Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology, 1999, vol. 145, pp. 283–291.
Manefield, M., Rasmussen, T.B., Henzter, M., Andersen, J.B., Steinberg, P., Kjelleberg, S., and Givskov, M., Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover, Microbiology, 2002, vol. 148, pp. 1119–1127.
Ren, D., Zuo, R., and Wood, T.K., Quorum-sensing antagonist (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone influences siderophore biosynthesis in Pseudomonas putida and Pseudomonas aeruginosa,Appl. Microbiol. Biotechnol., 2005, vol. 66, pp. 689–695.
Zahin, M., Hasan, S., Aqil, F., Khan, M.S., Husain, F.M., and Ahmad, I., Screening of certain medicinal plants from India for their anti-quorum sensing activity, Indian J. Exp. Biol., 2010, vol. 48, pp. 1219–1224.
Zhu, H., Liu, W., Tian, B., Liu, H., and Ning, S., Inhibition of quorum sensing in the opportunistic pathogenic bacterium Chromobacterium violaceum by an extract from fruiting bodies of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (higher basidiomycetes), Int. J. Med. Mushrooms, 2011, vol. 13, pp. 559–564.
Schulz, S., Dickschat, J.S., Kunze, B., Wagner-Dobler, I., Diestel, R., and Sasse, F., Biological activity of volatiles from marine and terrestrial bacteria, Mar. Drugs, 2010, vol. 8, pp. 2976–2987.
Balick, M.J. and Cox, P.A., Plants, People, and Culture: The Science of Ethnobotany, New York: Scientific American Library, 1999.
Lacassie, E., Marquet, P., Martin-Dupont, S., Gaulier, J.M., and Lachatre, G., A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-electrospray-mass spectrometry, J. Forensic Sci., 2000, vol. 45, pp. 1154–1158.
Bussey, H.I., Hawkins, D.W., Gaspard, J.J., and Walsh, R.A., A comparative trial of digoxin and digitoxin in the treatment of congestive heart failure, Pharmacotherapy, 1988, vol. 8, pp. 235–240.
Downie, J.A., The roles of extracellular proteins, polysaccharides and signals in the interactions of rhizobia with legume roots, FEMS Microbiol. Rev., 2010, vol. 34, pp. 150–170.
Khafagi, I.K. and Dewedar, A., The efficiency of random versus ethno-directed research in the evaluation of Sinai medicinal plants for bioactive compounds, J. Ethnopharmacol., 2000, vol. 71, pp. 365–376.
Dewick, P.M., Medicinal Natural Products: A Biosynthetic Approach, New York: Wiley, 2002, 2nd ed.
Cowan, M.M., Plant products as antimicrobial agents, Clin. Microbiol. Rev., 1999, vol. 12, pp. 564–582.
Tsao, C.Y., Wang, L., Hashimoto, Y., Yi, H., March, J.C., DeLisa, M.P., Wood, T.K., Valdes, J.J., and Bentley, W.E., LuxS coexpression enhances yields of recombinant proteins in Escherichia coli in part through posttranscriptional control of GroEL, Appl. Environ. Microbiol., 2011, vol. 77, pp. 2141–2152.
Kim, K., Kim, Y.U., Koh, B.H., Hwang, S.S., Kim, S.H., Lepine, F., Cho, Y.H., and Lee, G.R., HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kappaB pathway, Immunology, 2010, vol. 129, pp. 578–588.
Wang, Y., Deng, C., Peng, Q., Chen, Z., Huang, D., Zhang, J., and Song, F., Effect of quorum sensing response regulator nprR deletion on expression of cry protein in Bacillus thuringiensis,Wei Sheng Wu Xue Bao, 2010, vol. 50, pp. 1550–1555.
Diţu, L.M., Chifiriuc, C., Lazar, V., and Mihaescu, G., Implication of quorum sensing phenomenon in the expression of genes that code for bacteriocines in lactic bacteria, Bacteriol. Virusol. Parazitol. Epidemiol., 2009, vol. 54, pp. 147–166.
Lazar, V., Miyazaki, Y., Hanawa, T., Chifiriuc, M.C., Diţu, L.M., Maruţescu, L., Bleotu, C., and Kamiya, S., The influence of some probiotic supernatants on the growth and virulence features expression of several selected enteroaggregative E. coli clinical strains, Roum. Arch. Microbiol. Immunol., 2009, vol. 68, pp. 207–214.
Blumenthal, M., Goldberg, A., and Brinckmann, J., Herbal Medicine: Expanded Commission E Monographs, Newton, MA: Integrat. Med. Comm., 2000.
Chun, S.S., Vattem, D.A., Lin, Y.T., and Shetty, K., Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori,Proc. Biochem., 2005, vol. 40, pp. 809–816.
Rodrigues, M.R., Krause, L.C., Caramo, E.B., dos Santos, J.G., Dariva, C., and Vladimir de Oliveira, J., Chemical composition and extraction yield of the extract of Origanum vulgare obtained from sub- and supercritical CO2, J. Agric. Food Chem., 2004, vol. 52, pp. 3042–3047.
Chami, F., Chami, N., Bennis, S., Trouillas, J., and Remmal, A., Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model, J. Antimicrob. Chemother., 2004, vol. 54, pp. 909–914.
Hersch-Martinez, P., Leanos-Miranda, B.E., and Solórzano-Santos, F., Antibacterial effects of commercial essential oils over locally prevalent pathogenic strains in Mexico, Fitoterapia, 2005, vol. 76, pp. 453–457.
Saeed, A.M. and Sabir, A.W., Antibacterial activities of some constituents from oleo-gum-resin of Commiphora mukul,Fitoterapia, 2004, vol. 75, pp. 204–208.
Mendez, C. and Salas, J.A., The role of ABC transporters in antibiotic-producing organisms: Drug secretion and resistance mechanisms, Res. Microbiol., 2001, vol. 152, pp. 341–350.
Hogan, D.A., Vik, A., and Kolter, R., A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology, Mol. Microbiol., 2004, vol. 54, pp. 1212–1223.
Persson, T., Hansen, T.H., Rasmussen, T.B., Skindersoe, M.E., Givskov, M., and Neilsen, J., Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic, Org. Biomol. Chem., 2005, vol. 3, pp. 253–262.
Rasmussen, T.B., Bjarnsholt, T., Skindersoe, M.E., Hentzer, M., Kristoffersen, P., Kote, M., Nielsen, J., Eberl, L., and Givskov, M., Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI Selector, J. Bacteriol., 2005, vol. 187, pp. 1799–1814.
Teplitski, M., Robinson, J.B., and Bauer, W.D., Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density–dependent behaviors in associated bacteria, Mol. Plant–Microbe Interact., 2000, vol. 13, pp. 637–648.
Vattem, D.A., Mihalik, K., Crixell, S.H., and McLean, R.J.C., Dietary phytochemicals as quorum sensing inhibitors, Fitoterapia, 2007, vol. 78, pp. 302–310.
Nascimento, G.G.F., Locatelli, J., Freitas, P.C., and Silva, G.L., Antimicrobial activity of plant extracts and phytochemicals on antibiotic resistant bacteria, Braz. J. Microbiol., 2000, vol. 31, pp. 247–256.
Walker, T.S., Bais, H.P., Deziel, E., Schweizer, H.P., Rahme, L.G., Fall, R., and Vivanco, J.M., Pseudomonas aeruginosa–plant root interactions. Pathogenicity, biofilm formation, and root exudation, Plant Physiol., 2004, vol. 134, pp. 320–331.
Huber, B., Eberl, L., Feucht, W., and Polster, J., Influence of polyphenols on bacterial biofilm formation and quorum-sensing, Z. Naturforsch. C: Biosci., 2004, vol. 58, pp. 879–884.
Al-Hussaini, R. and Mahasneh, A.M., Microbial growth and quorum sensing antagonist activities of herbal plants extracts, Molecules, 2009, vol. 14, pp. 3425–3435.
Krishnan, T., Yin, W.F., and Chan, K.G., Inhibition of quorum sensing controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium Aromaticum) bud extract, Sensors, 2012, vol. 12, pp. 4016–4030.
Boga, C., Forlani, L., Calienni, R., Hindley, T., Hochkoeppler, A., Tozzi, S., and Zanna, N., On the antibacterial activity of roots of Capparis spinosa L., Nat. Prod. Res., 2011, vol. 25, pp. 417–421.
Issac Abraham, S.V., Palani, A., Ramaswamy, B.R., Shunmugiah, K.P., and Arumugam, V.R., Antiquorum sensing and antibiofilm potential of Capparis spinosa,Arch. Med. Res., 2011, vol. 42, pp. 658–668.
Chong, Y.M., Yin, W.F., Ho, C.Y., Mustafa, M.R., Hadi, A.H.A., Awang, K., Narrima, P., and Koh, C.L., Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity, J. Nat. Prod., 2011, vol. 74, pp. 2261–2264.
Singh, B.N., Singh, H.B., Singh, A., Singh, B.R., Mishra, A., and Nautiyal, C.S., Lagerstroemia speciosa fruit extract modulates quorum sensing-controlled virulence factor production and biofilm formation in Pseudomonas aeruginosa,Microbiology, 2012, vol. 158, pp. 529–538.
Tan, L.Y., Yin, W.F., and Chan, K.G., Silencing quorum sensing through extracts of Melicope lunu-ankenda,Sensors, 2012, vol. 12, pp. 4339–4351.
Yeo, S.S.M. and Tham, F.Y., Anti-quorum sensing and antimicrobial activities of some traditional Chinese medicinal plants commonly used in South-East Asia, Malaysian J. Microbiol., 2012, vol. 8, pp. 11–20.
Ronald, P.C., Small protein-mediated quorum sensing in a Gram-negative bacterium: Novel targets for control of infectious disease, Discov. Med., 2011, vol. 12, pp. 461–470.
Bouyahya, A., Dakka, N., Et-Touys, A., Abrini, J., and Bakri, Y., Medicinal plant products targeting quorum sensing for combating bacterial infections, Asian Pac. J. Trop. Med., 2017, vol. 10, no. 8, pp. 729–743.
Kalia, V.C., Quorum sensing inhibitors: An overview, Biotechnol. Adv., 2013, vol. 31, pp. 224–245.
Amara, N., Krom, B.P., Kaufmann, G.F., and Meijler, M.M., Macromolecular inhibition of quorum sensing: Enzymes, antibodies, and beyond, Chem. Rev., 2011, vol. 111, pp. 195–208.
Kalia, V.C. and Purohit, H.J., Quenching the quorum sensing system: Potential antibacterial drug targets, Crit. Rev. Microbiol., 2011, vol. 37, pp. 121–140.
Smith, R.S. and Iglewski, B.H., Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target, J. Clin Invest., 2003, vol. 112, pp. 1460–1465.
Rasmussen, T.B. and Givskov, M., Quorum sensing inhibitors: A bargain of effects, Microbiology, 2006, vol. 152, pp. 895–904.
Miyairi, S., Tateda, K., Fuse, E.T., Ueda, C., Saito, H., et al., Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection, J. Med. Microbiol., 2006, vol. 55, pp. 1381–1387.
Hirakawa, H., Harwood, C.S., Pechter, K.B., Schaefer, A.L., and Greenberg, E.P., Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression, Proc. Natl. Acad. Sci. U. S. A., 2012, vol. 109, pp. 12 141–12 146.
Umesha, S. and Shivakumar, J., Bacterial quorum sensing and it is applications in biotechnology, Int. J. Pharm. Biol. Sci., 2013, vol. 4, pp. 850–861.
Winson, M.K., Swift, S., Fish, L., Throup, J.P., Jørgensen, F., et al., Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing, FEMS Microbiol. Lett., 1998, vol. 163, pp. 185–192.
Steindler, L. and Venturi, V., Detection of quorum-sensing N-acyl homoserine lactone signal molecules by bacterial biosensors, FEMS Microbiol. Lett., 2007, vol. 266, pp. 1–9.
Yu, Y.A., Shabahang, S., Timiryasova, T.M., Zhang, Q., Beltz, R., et al., Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins, Nat. Biotechnol., 2004, vol. 22, pp. 313–320.
Anderson, J.C., Clarke, E.J., Arkin, A.P., and Voigt, C.A., Environmentally controlled invasion of cancer cells by engineered bacteria, J. Mol Biol., 2006, vol. 355, pp. 619–627.
Dong, Y., Wang, L.H., and Zhang, L.H., Quorum-quenching microbial infections: Mechanisms and implications, Philos. Trans. R. Soc. Lond. B: Biol. Sci., 2007, vol. 362, pp. 1201–1211.
Moghaddam, M.M., Khodi, S., and Mirhosseini, A., Quorum sensing in bacteria and a glance on Pseudomonas aeruginosa,Clin. Microbiol., 2014, vol. 3, p. 156. https://doi.org/10.4172/2327-5073.1000156
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
COMPLIANCE WITH ETHICAL STANDARDS
This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the authors.
Conflict of Interests
The authors declare that they have no conflicts of interest.
Additional information
Corresponding author: phone: +91-9897088910; e-mail: aasif321@gmail.com.
Rights and permissions
About this article
Cite this article
Asif, M., Imran, M. Effect of Quorum Sensing Inhibitor Agents against Pseudomonas aeruginosa. Russ J Bioorg Chem 46, 149–164 (2020). https://doi.org/10.1134/S1068162020020041
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1068162020020041