Abstract
Targeted cationic liposomes containing folate lipoconjugates with spacer groups of various lengths and natures were prepared; their physicochemical characteristics and their transfection activity towards KB-3-1 and HEK 293 cells were determined. Targeted delivery of plasmid DNA was studied by competitive inhibition of DNA delivery in the presence of free folic acid.
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The work was financially supported by the Russian Science Foundation (project no. 18-73-00270).
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Translated by G. Levit
Abbreviations: 2X3, 1,26-bis(cholest-5-ene-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosane tetrahydrochloride; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; EGFP, enhanced green fluorescent protein; FA, folic acid; FBS, fetal bovine serum; NAs, nucleic acids; pDNA, plasmid DNA.
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Shmendel, E.V., Kabilova, T.O., Morozova, N.G. et al. Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells. Russ J Bioorg Chem 45, 719–725 (2019). https://doi.org/10.1134/S1068162019060360
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DOI: https://doi.org/10.1134/S1068162019060360