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Synthesis of Amides of Carboxylic Acids with an Imide and Alicyclic Fragments and a Study of Their Genotoxic Activity in the Allium Test

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Abstract—

A method for the high-yield synthesis of several amides of carboxylic acids containing an imide, a cyclohexene, and a norbornene cycle as well as fragments of natural amino acids has been developed. The compounds synthesized have been tested for mutagenic activity on plant objects using the Allium test. It has been shown that the presence of a nitro group endows the compound with inhibitory property and the capacity to induce chromosomal rearrangements, whereas the presence of an aliphatic carbon chain, a methyl group, and a morpholine fragment, on the contrary, confers growth-regulating properties without inducing the mutagenic effect. The study has confirmed that the resulting biologically active compounds are of interest for practical implementation in agriculture.

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Authors and Affiliations

  1. Yaroslavl State Technical University, 150001, Yaroslavl, Russia

    A. A. Firstova, E. R. Kofanov & V. M. Zakshevskaya

  2. Demidov Yaroslavl State University, 150003, Yaroslavl, Russia

    M. I. Kovaleva

Authors
  1. A. A. Firstova
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  2. E. R. Kofanov
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  3. V. M. Zakshevskaya
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  4. M. I. Kovaleva
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Correspondence to A. A. Firstova.

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Translated by S. Sidorova

Abbreviations: CDI, N,N'-carbonyldiimidazole; QSAR,   Quantitative Structure-Activity Relationship. 1Corresponding author: phone: +7(960)528-25-77; e-mail:   firstova.a.a@mail.ru.

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Firstova, A.A., Kofanov, E.R., Zakshevskaya, V.M. et al. Synthesis of Amides of Carboxylic Acids with an Imide and Alicyclic Fragments and a Study of Their Genotoxic Activity in the Allium Test. Russ J Bioorg Chem 45, 204–213 (2019). https://doi.org/10.1134/S1068162019030026

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  • DOI: https://doi.org/10.1134/S1068162019030026

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