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Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids

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Abstract

The paper reports on the synthesis of a series of acyl derivatives of betulin and dihydroquinopimaric acid and the study of their antiviral activity against influenza A virus (H7N1), herpes simplex virus type 1 (HSV-1), ECHO 6, and HIV-1 in comparison with the activity of the previously obtained acylates and original terpenoids. It has been demonstrated that acylated betulin and betulinic acid show no advantage in inhibiting the reproduction of all the tested viruses compared with the betulic acid, while structural modifications at positions C3 and C28 of the triterpene core led to some changes in the spectrum of antiviral activity. Modification of dihydroquinopimaric acid at position C4 increased the activity of this compound against influenza virus A (H7N1).

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Autonomous Structural Unit of the Ufa Federal Research Centre, Russian Academy of Science, Ufa, 450054, Russia

    O. B. Kazakova, I. E. Smirnova & L. A. Baltina

  2. Republican Research and Practice Center for Epidemiology and Microbiology, Minsk, 220114, Belarus

    E. I. Boreko & O. V. Savinova

  3. Vector State Research Center of Virology and Biotechnology, Kоltsovo, Novosibirsk oblast, 630059, Russia

    A. G. Pokrovskii

Authors
  1. O. B. Kazakova
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  2. I. E. Smirnova
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  3. L. A. Baltina
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  4. E. I. Boreko
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  5. O. V. Savinova
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  6. A. G. Pokrovskii
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Correspondence to O. B. Kazakova.

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Kazakova, O.B., Smirnova, I.E., Baltina, L.A. et al. Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids. Russ J Bioorg Chem 44, 740–744 (2018). https://doi.org/10.1134/S1068162018050059

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  • DOI: https://doi.org/10.1134/S1068162018050059

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