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Profile of Gene Expression in the Kidneys of Mice with the insrr Gene Knockout

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Abstract

The insulin receptor-related receptor (IRR) is a receptor tyrosine kinase and a close homologue of the insulin receptor and the insulin-like growth factor receptor; however, peptide and protein ligands for this receptor have not been identified. IRR is encoded by the insrr gene and is found in some cell populations of kidneys, stomach, pancreas, as well as in some sympathetic and cholinergic neurons. In the present study, a comparative analysis of the transcriptomes of kidneys from wild-type mice and IRR-knockout mice has been performed by the method of deep sequencing and by the analysis of gene expression on microarrays and in real-time PCR. A significant change (a more than 1.5fold increase in gene expression in knockout animals) was found for the transcripts of two genes: hsd3b2 and igf2. The results suggest that the line of IRR-knockout mice can find application as an animal model in studies of the role of these genes in the kidney.

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References

  1. Tatulian, S.A., Biochemistry, 2015, vol. 54, pp. 5523–5532.

    Article  CAS  PubMed  Google Scholar 

  2. Deyev, I.E., Sohet, F., Vassilenko, K.P., Serova, O.V., Popova, N.V., Zozulya, S.A., Burova, E.B., Houillier, P., Rzhevsky, D.I., Berchatova, A.A., et al., Cell Metab., 2011, vol. 13, pp. 679–689.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Deyev, I.E., Mitrofanova, A.V., Zhevlenev, E.S., Radionov, N., Berchatova, A.A., Popova, N.V., Serova, O.V., and Petrenko, A.G., J. Biol. Chem., 2013, vol. 288, pp. 33884–33893.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Deyev, I.E., Chachina, N.A., Shayahmetova, D.M., Serova, O.V., and Petrenko, A.G., Biochimie, 2015, vol. 111, pp. 1–9.

    Article  CAS  PubMed  Google Scholar 

  5. Deyev, I.E., Popova, N.V., and Petrenko, A.G., Acta Naturae, 2015, vol. 7, pp. 80–86.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Petrenko, A.G., Zozulya, S.A., Deyev, I.E., and Eladari, D., Biochim. Biophys. Acta, 2013, vol. 1834, pp. 2170–2175.

    Article  CAS  PubMed  Google Scholar 

  7. Mathi, S.K., Chan, J., and Watt, V.M., Endocrinology, 1995, vol. 136, pp. 4125–4132.

    Article  CAS  PubMed  Google Scholar 

  8. Ozaki, K., Takada, N., Tsujimoto, K., Tsuji, N., Kawamura, T., Muso, E., Ohta, M., and Itoh, N., Kidney Int., 1997, vol. 52, pp. 694–698.

    Article  CAS  PubMed  Google Scholar 

  9. Bates, C.M., Merenmies, J.M., Kelly-Spratt, K.S., and Parada, L.F., Kidney Int., 1997, vol. 52, pp. 674–681.

    Article  CAS  PubMed  Google Scholar 

  10. Deyev, I.E., Rzhevsky, D.I., Berchatova, A.A., Serova, O.V., Popova, N.V., Murashev, A.N., and Petrenko, A.G., Acta Naturae, 2011, vol. 3, pp. 114–117.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Zubkov, E.A., Chachina, N.A., Shayakhmetova, D.M., Mozhaev, A.A., Deyev, I.E., Chekhonin, V.P., and Petrenko, A.G., Zh. Vyssh. Nerv. Deyat., 2017, vol. 67, pp. 106–112.

    Google Scholar 

  12. O'Dell, S.D. and Day, I.N.M., Int. J. Biochem. Cell Biol., 1998, vol. 30, pp. 767–771.

    Article  PubMed  Google Scholar 

  13. Jui, H.Y., Suzuki, Y., Accili, D., and Taylor, S.I., J. Biol. Chem., 1994, vol. 269, pp. 22446–22452.

    CAS  PubMed  Google Scholar 

  14. Maschietto, M., Charlton, J., Perotti, D., Radice, P., Geller, J.I., Pritchard-Jones, K., and Weeks, M., Oncotarget, 2014, vol. 5, pp. 8014–8026.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Hubertus, J., Lacher, M., Rottenkolber, M., Muller-Hocker, J., Berger, M., Stehr, M., Von Schweinitz, D., and Kappler, R., Oncol. Rep., 2011, vol. 25, pp. 817–823.

    Article  CAS  PubMed  Google Scholar 

  16. Pelletier, G., Dupont, E., Simard, J., Luuthe, V., Belanger, A., and Labrie, F., J. Steroid Biochem. Mol. Biol., 1992, vol. 43, pp. 451–467.

    Article  CAS  PubMed  Google Scholar 

  17. Pezzi, V., Mathis, J.M., Rainey, W.E., and Carr, B.R., J. Steroid Biochem. Mol. Biol., 2003, vol. 87, pp. 181–189.

    Article  CAS  PubMed  Google Scholar 

  18. Lubik, A.A., Gunter, J.H., Hollier, B.G., Ettinger, S., Fazli, L., Stylianou, N., Hendy, S.C., Adomat, H.H., Gleave, M.E., Pollak, M., et al., Endocrine-Related Cancer, 2013, vol. 20, pp. 173–186.

    Article  CAS  PubMed  Google Scholar 

  19. Shayahmetova, D.M., Zhevlenev, E.S., Mozhaev, A.A., Deyev, I.E., and Petrenko, A.G., Russ J. Bioorg. Chem., 2016, vol. 42, no. 449–452.

    Google Scholar 

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia

    I. E. Deyev, D. M. Shayahmetova, N. V. Radionov & A. G. Petrenko

  2. Federal Research Center Fundamental Bases of Biotechnology, Russian Academy of Sciences, Moscow, 119991, Russia

    S. V. Zhenilo

Authors
  1. I. E. Deyev
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  2. D. M. Shayahmetova
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  3. S. V. Zhenilo
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  4. N. V. Radionov
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  5. A. G. Petrenko
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Correspondence to I. E. Deyev.

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Original Russian Text © I.E. Deyev, D.M. Shayahmetova, S.V. Zhenilo, N.V. Radionov, A.G. Petrenko, 2018, published in Bioorganicheskaya Khimiya, 2018, Vol. 44, No. 2, pp. 238–243.

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Deyev, I.E., Shayahmetova, D.M., Zhenilo, S.V. et al. Profile of Gene Expression in the Kidneys of Mice with the insrr Gene Knockout. Russ J Bioorg Chem 44, 256–260 (2018). https://doi.org/10.1134/S1068162018020115

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  • DOI: https://doi.org/10.1134/S1068162018020115

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