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Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments

Abstract

The antimicrobial activity and cytotoxicity of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments in alkyl chains have been studied. The compounds have been tested for the antimicrobial activity toward some gram-positive and gram-negative bacteria and fungal cultures. The cytotoxic action has been estimated toward mammalian cells. It has been found that the basic structural factor that affects the antimicrobial activity is the nature of alkyl radicals at triazole fragments.

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Abbreviations

MIC:

minimal inhibitory concentration

MBC:

minimal bactericidal concentration

MFC:

minimal fungicidal concentration

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Correspondence to A. D. Voloshina.

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Proceedings of the Conference Chemical Biology-2016, (Novosibirsk, 24–29 July 2016).

Original Russian Text © A.D. Voloshina, V.E. Semenov, A.S. Strobykina, N.V. Kulik, E.S. Krylova, V.V. Zobov, V.S. Reznik, 2017, published in Bioorganicheskaya Khimiya, 2017, Vol. 43, No. 2, pp. 197–204.

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Voloshina, A.D., Semenov, V.E., Strobykina, A.S. et al. Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments. Russ J Bioorg Chem 43, 170–176 (2017). https://doi.org/10.1134/S1068162017020170

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  • DOI: https://doi.org/10.1134/S1068162017020170

Keywords

  • triazoles
  • uracils
  • antimicrobial activity
  • cytotoxicity
  • hemolytic activity