Abstract
New esters of N-benzoyl-3-phenoxyphenylcarboxamide acid and N-benzoyl-N′-4-bromophenyl-3-phenoxybenzamidine were synthesized. Some of the synthesized compounds were shown to inhibit the activity of dipeptidyl peptidase-4 and nonenzymatic glycosylation of proteins and manifested antiplatelet and antioxidant properties. The compounds tested did not display the antagonistic effect toward angiotensin II type 1 receptor, did not influence the activity of glycogen phosphorylase and had very little ability to break cross-links of the glycated proteins. The derivatives with the biological activity of two types were found, which can serve as basic molecules in the search for new drug products.
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Abbreviations
- AT1 :
-
angiotensin type 1 receptor
- DPP-4:
-
dipeptidyl peptidase-4
- GP:
-
glycogen phosphorylase
- LPO:
-
lipid peroxidation
- TBA:
-
thiobarbituric acid
- TEA:
-
triethylamine
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Original Russian Text © A.A. Spasov, Yu.V. Popov, V.S. Lobasenko, T.K. Korchagina, P.M. Vassiliev, V.A. Kuznetsova, A.A. Brigadirova, A.I. Rashchenko, D.A. Babkov, A.N. Kochetkov, A.I. Kovaleva, O.S. Efremova, 2017, published in Bioorganicheskaya Khimiya, 2017, Vol. 43, No. 2, pp. 189–196.
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Spasov, A.A., Popov, Y.V., Lobasenko, V.S. et al. Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives. Russ J Bioorg Chem 43, 163–169 (2017). https://doi.org/10.1134/S1068162017020145
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DOI: https://doi.org/10.1134/S1068162017020145