Skip to main content

The secreted protein Noggin4 is an activator of the Wnt/PCP-signaling pathway

Abstract

The protein Noggin4 of the African clawed frog Xenopus laevis has been shown to act as a modulator of the “noncanonical” Wnt/PCP-signaling pathway that plays an important role in the regulation of cell motility. Induction of disturbances in the expression of Noggin4 led to the activation of Wnt/PCP-pathway and the related anomalies of early embryonic development. The Noggin4 protein can bind the Wnt11 protein that normally contributes to the activation of the Wnt/PCP-pathway and of enhancing the activator effect of this protein in luciferase assays. Thus, Noggin4 can be used as a tool for specific experimental regulation of the activity of the Wnt/PCP pathway.

This is a preview of subscription content, access via your institution.

Abbreviations

BMP:

bone morphogenetic protein

Wnt/PCP:

Wnt/planar cell polarity

MO:

morpholino oligonucleotides

References

  1. Smith, W.C. and Harland, R.M., Cell, 1992, vol. 70, pp. 829–840.

    CAS  Article  PubMed  Google Scholar 

  2. Bayramov, A.V., Eroshkin, F.M., Martynova, N.Y., Ermakova, G.V., Solovieva, E.A., and Zaraisky, A.G., Development, 2011, vol. 138, no. 24, pp. 5345–5356.

    CAS  Article  PubMed  Google Scholar 

  3. Eroshkin, F.M., Nesterenko, A.M., Borodulin, A.V., Martynova, N.Yu., Ermakova, G.V., Gyoeva, F.K., Orlov, E.E., Belogurov, A.A., Lukyanov, K.A., Bayramov, A.V., and Zaraisky, A.G., Sci. Rep., 2016, vol. 6, p. 23049.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. Bairamov, A.V., Eroshkin, F.M., Borodulin, A.V., Martynova, N.Yu., Ermakova, G.V., and Zaraisky, A.G., Russ. J. Dev. Biol., 2016 (in press).

    Google Scholar 

  5. Tada, M. and Kai, M., Curr. Top. Dev. Biol., 2012, vol. 101, pp. 77–110.

    CAS  Article  PubMed  Google Scholar 

  6. Wallingford, J.B., Rowning, B.A., Vogeli, K.M., Rothbacher, U., Fraser, S.E., and Harland, R.M., Nature, 2000, vol. 405, pp. 81–85.

    CAS  Article  PubMed  Google Scholar 

  7. Mulligan, K.A. and Cheyette, B.N.R., J. Neuroimmune Pharmacol., 2012, vol. 7, no. 4, pp. 774–787.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kim, G.H., Park, E.C., and Han, J.K., Methods Mol. Biol., 2012, vol. 839, pp. 79–89.

    CAS  Article  PubMed  Google Scholar 

  9. Ohkawara, B. and Niehrs, C., Dev. Dynam., 2011, vol. 240, pp. 188–194.

    Article  Google Scholar 

  10. Martynova, N.Y., Eroshkin, F.M., Ermolina, L.V., Ermakova, G.V., Korotaeva, A.L., Smurova, K.M., Gyoeva, F.K., and Zaraisky, A.G., Dev. Dynam., 2008, vol. 237, pp. 736–749.

    CAS  Article  Google Scholar 

  11. Hikasa, H. and Sokol, S.Y., Cold Spring Harb. Perspect. Biol., 2013, vol. 5, no. 1, p. 007955.

    Article  Google Scholar 

  12. Eroshkin, F.M., Bairamov, A.V., Aver’yanova, O.V., Solov’eva, E.A., Serebryakova, M.V., Zaraisky, A.G., and Martynova, N.Yu., Russ. J. Bioorg. Chem., 2013, vol. 39, no. 2, pp. 218–222.

    CAS  Article  Google Scholar 

  13. Martynova, N.Yu., Nesterenko, A.M., Orlov, E.E., Eroshkin, F.M., Borodulin, A.V., Bairamov, A.V., and Zaraisky, A.G., Russ. J. Bioorg. Chem. 2016, vol. 48, no. 3, pp. 340–342.

    Article  Google Scholar 

  14. Martynova, N.Y., Eroshkin, F.M., Ermolina, L.V., Ermakova, G.V., Korotaeva, A.L., Smurova, K.M., Gyoeva, F.K., and Zaraisky, A.G., Dev. Dynam., 2008, vol. 237, pp. 736–749.

    CAS  Article  Google Scholar 

  15. Cohen, E.D., Miller, M.F., Wang, Z., Moon, R.T., and Morrisey, E.E., Development, 2012, vol. 139, no. 11, pp. 1931–1940.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to A. V. Bayramov or A. G. Zaraisky.

Additional information

Original Russian Text © A.V. Bayramov, F.M. Eroshkin, N.Y. Martynova, E.E. Orlov, A.V. Borodulin, A.G. Zaraisky, 2017, published in Bioorganicheskaya Khimiya, 2017, Vol. 43, No. 2, pp. 214–217.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bayramov, A.V., Eroshkin, F.M., Martynova, N.Y. et al. The secreted protein Noggin4 is an activator of the Wnt/PCP-signaling pathway. Russ J Bioorg Chem 43, 216–219 (2017). https://doi.org/10.1134/S1068162017020029

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162017020029

Keywords

  • Noggin
  • Noggin4
  • Wnt/PCP
  • Wnt5a
  • Wnt11