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KLF5, a new player and new target in the permanently changing set of pancreatic cancer molecular drivers

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Abstract

Pancreatic cancer is one of the most aggressive tumor types characterized by chemotherapy resistance and high metastatic activity. Recent studies revealed new genes, which are likely to be actively involved in the regulation of the processes occurring in the pancreas, as well as in the development of cancer in this organ. This review is devoted to the description of one of the recently revealed genes, KLF5, which seems to be a promising target for therapeutic intervention in the most widespread type of pancreatic cancer, ductal adenocarcinoma.

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Abbreviations

PDAC:

pancreatic ductal adenocarcinoma

ESCs:

embryonic stem cells

EMT:

epithelial-mesenchymal transition

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia

    M. V. Zinovyeva, M. B. Kostina, I. P. Chernov, L. G. Kondratyeva & E. D. Sverdlov

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  1. M. V. Zinovyeva
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  2. M. B. Kostina
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  3. I. P. Chernov
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  4. L. G. Kondratyeva
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  5. E. D. Sverdlov
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Correspondence to M. V. Zinovyeva.

Additional information

Original Russian Text © M.V. Zinovyeva, M.B. Kostina, I.P. Chernov, L.G. Kondratyeva, E.D. Sverdlov, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 6, pp. 668–674.

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Zinovyeva, M.V., Kostina, M.B., Chernov, I.P. et al. KLF5, a new player and new target in the permanently changing set of pancreatic cancer molecular drivers. Russ J Bioorg Chem 42, 606–611 (2016). https://doi.org/10.1134/S1068162016060157

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