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Adaptive features of natural killer cells, lymphocytes of innate immunity

Russian Journal of Bioorganic Chemistry volume 42, pages 590–605 (2016)Cite this article

Abstract

Natural killer cells (NK cells) are traditionally attributed to the innate immune system. It is considered that previously received stimuli have little effect on the functioning of these immune cells. Indeed, NK cells even without prior sensitization provide a rapid effector response against tumor, virus-infected, or otherwise damaged cells. They have a limited repertoire of receptors, the expression of which does not require somatic recombination. However, recent data indicate that NK cells may acquire the properties specific to adaptive immune cells. In particular, NK cells have been shown to possess the features of immunological memory, namely, the ability to more quickly and effectively respond to a repeated stimulus. The mechanisms of memory acquisition in NK cells differ from those implemented in T and B lymphocytes and are still rather vague. Presumably, some of these mechanisms underlie the significant phenotypic and functional NK cell diversity emerging during their differentiation. The recent data accumulated in this area considerably change the existing immunology paradigm, which postulates a clear delineation of the adaptive and innate immune cells. The published data on phenotypic and functional characteristics of NK cells and particular changes in these characteristics during NK cell differentiation and generation of memory-like NK cells are reviewed.

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Abbreviations

ADCC:

antibody-dependent cell-mediated cytotoxicity

aKIRs:

activating KIRs

CLP:

common lymphoid progenitor

HCMV:

human cytomegalovirus

IFNγ:

interferon-γ

IL:

interleukin

IL-2(12,15,18)R:

IL-2(12,15,18) receptors

ILCs:

innate lymphoid cells

ITAM:

immunoreceptor tyrosinebased activation motif

ITIM:

immunoreceptor tyrosine-based inhibition motif

KIR:

killer-cell immunoglobulin-like receptor family

MHC:

major histocompatibility complex

NCRs:

natural cytotoxicity receptors

NK cells:

natural killer cells

PI3K:

phosphatidylinositol-3-kinase

PLC:

phospholipase C

RAGs:

recombination activating genes

SLAM:

signaling lymphocyte activation molecule.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia

    E. I. Kovalenko & M. A. Streltsova

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  1. E. I. Kovalenko
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Original Russian Text © E.I. Kovalenko, M.A. Streltsova, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 6, pp. 649–667.

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Kovalenko, E.I., Streltsova, M.A. Adaptive features of natural killer cells, lymphocytes of innate immunity. Russ J Bioorg Chem 42, 590–605 (2016). https://doi.org/10.1134/S1068162016060066

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Keywords

  • natural killer cells
  • adaptive NK cells
  • immunological memory
  • NK cell differentiation
  • NK cell activation