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Aminooxy adsorbents derived from sephareose and toyopearl

Abstract

Convenient synthetic schemes being suitable for the preparation of aminooxy-Sepharose and hydroxylamine-containing Toyopearl with capacity of 0.35–0.015 mmols of H2NO-groups per mL gel, including the adsorbent with easily cleavable disulfide bond in the linker are developed.

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Abbreviations

PLP:

pyridoxal-5′-phosphate

DTT:

dithiothreitol

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Correspondence to A. R. Khomutov.

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Original Russian Text © M.A. Khomutov, P.N. Solyev, S.N. Kochetkov, A.R. Khomutov, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 5, pp. 603–607.

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Khomutov, M.A., Solyev, P.N., Kochetkov, S.N. et al. Aminooxy adsorbents derived from sephareose and toyopearl. Russ J Bioorg Chem 42, 546–550 (2016). https://doi.org/10.1134/S1068162016050095

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  • DOI: https://doi.org/10.1134/S1068162016050095

Keywords

  • О-substituted hydroxylamines
  • adsorbents
  • Sepharose
  • Toyopearl