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Novel 3-pyridinecarbonitriles incorporating sulfonamide moieties as anti-breast cancer agents

Abstract

A novel series of 3-pyridinecarbonitrile derivatives incorporating sulfonamide moieties and sulfonyl derivatives was synthesized using 2-chloro-6-methylnicotinonitrile as a strategic starting material. The structures of the synthesized compounds were elucidated on the basis of elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data. All the prepared compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF-7). Most of the compounds showed good to moderate activity, higher than that of the reference drug doxorubicin. Two compounds showed the same activity as doxorubicin, while three compounds exhibited remarkable activity.

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Correspondence to Mostafa M. Ghorab.

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Ghorab, M.M., Alsaid, M.S. Novel 3-pyridinecarbonitriles incorporating sulfonamide moieties as anti-breast cancer agents. Russ J Bioorg Chem 42, 441–448 (2016). https://doi.org/10.1134/S1068162016040087

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  • DOI: https://doi.org/10.1134/S1068162016040087

Keywords

  • synthesis
  • 3-pyridinecarbonitrile
  • sulfonamide
  • anti-breast cancer activity