Abstract
We demonstrated that the secreted protein Noggin4 from Xenopus laevis was capable of the in vitro binding to the secreted factor Wnt8, one of the ligands of the Wnt/betaCatenin signaling pathway. It was also shown that posttranslational modifications occurring during secretion of these proteins from the embryonic cells were necessary for their effective interaction. Also, we proposed a method for the preparation of physiologically active secreted morphogenic proteins from the intercellular space of the Xenopus laevis embryos.
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Original Russian Text © N.Y. Martynova, A.M. Nesterenko, E.E. Orlov, F.M. Eroshkin, A.V. Borodulin, A.V. Bayramov, A.G. Zaraisky, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 3, pp. 374–378.
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Martynova, N.Y., Nesterenko, A.M., Orlov, E.E. et al. The interaction of secreted proteins Noggin4 and Wnt8 from Xenopus laevis embryos. Russ J Bioorg Chem 42, 340–342 (2016). https://doi.org/10.1134/S1068162016030110
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DOI: https://doi.org/10.1134/S1068162016030110