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Anthelmintic and antibacterial screening of a new series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines

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Abstract

A series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines was synthesized. Structural elucidation was accomplished by 1H NMR, 13C NMR, IR, and elemental analyses of synthesized compounds. The title compounds were derived from 4-(4-nitrophenoxy)phenyl thiourea, which is the key intermediate in the synthesis of nitroscanate, an anthelmintic drug. Among the synthesized compounds, N-[4-(4-nitrophenoxy)phenyl]-4-(4-fluorophenyl)-1,3-thiazol-2-amine and N-[4-(4-nitrophenoxy)phenyl]-4-(4-methoxyphenyl)-1,3-thiazol-2-amine exhibited potent anthelmintic and antibacterial activities.

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Authors and Affiliations

  1. Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal, 576104, India

    Namratha Bhandari & Santosh L. Gaonkar

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  1. Namratha Bhandari
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  2. Santosh L. Gaonkar
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Correspondence to Santosh L. Gaonkar.

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Bhandari, N., Gaonkar, S.L. Anthelmintic and antibacterial screening of a new series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines. Russ J Bioorg Chem 42, 210–214 (2016). https://doi.org/10.1134/S1068162016020096

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  • DOI: https://doi.org/10.1134/S1068162016020096

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