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The synthesis of oligosaccharides containing internal and terminal Galβ1-3GlcNAcβ fragments

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Abstract

Oligosaccharides Galβ1-3GlcNAcβ-sp, GlcNAcβ1-3Galβ1-3GlcNAcβ-sp, Galβ1-3GlcNAcβ1-3Galβ1-3GlcNAcβ-sp, Galβ1-3GlcNAcβ1-3Galβ1-4GlcNAcβ-sp, Galβ1-3GlcNAcβ1-6Galβ1-4GlcNAcβ-sp (sp = O(CH2)3NH2 or O(CH2)2NH2) were synthesized using glycosylation with N-Troc-protected derivatives of glucosamine or disaccharide Lec.

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Abbreviations

Bn:

benzyl

Lec :

Galβ1-3GlcNAcβ

AgOTf:

silver triflate

TMM:

tetramethylurea

Troc:

2,2,2-trichloroethoxycarbonyl

TMSEt:

β-trimethylsilylethyl

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Authors and Affiliations

  1. Research Institute of Physicochemical Medicine of Federal Medical and Biological Agency, ul. Malaya Pirogovskaya 1a, Moscow, 119435, Russia

    V. V. Severov

  2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    G. V. Pazynina, T. V. Ovchinnikova & N. V. Bovin

Authors
  1. V. V. Severov
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  2. G. V. Pazynina
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  3. T. V. Ovchinnikova
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  4. N. V. Bovin
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Corresponding author

Correspondence to N. V. Bovin.

Additional information

Original Russian Text © V.V. Severov, G.V. Pazynina, T.V. Ovchinnikova, N.V. Bovin, 2015, published in Bioorganicheskaya Khimiya, 2015, Vol. 41, No. 2, pp. 170–184.

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Severov, V.V., Pazynina, G.V., Ovchinnikova, T.V. et al. The synthesis of oligosaccharides containing internal and terminal Galβ1-3GlcNAcβ fragments. Russ J Bioorg Chem 41, 147–160 (2015). https://doi.org/10.1134/S1068162015020120

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  • DOI: https://doi.org/10.1134/S1068162015020120

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