Molecular complexes of ivy and licorice saponins with sildenafil citrate (Viagra) and their biological activity
- First Online:
- Cite this article as:
- Yakovishin, L.A., Lekar, A.V., Vetrova, E.V. et al. Russ J Bioorg Chem (2014) 40: 737. doi:10.1134/S1068162014070188
- 63 Downloads
The molecular complexation of triterpene glycosides α-hederin (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranoside), hederasaponin C (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(l → 4)-O-β-D-glucopyranosyl-(l → 6)-O-β-D-glucopyranoside), and glycyram (monoammonium glycyrrhizinate) with sildenafil citrate was investigated for the first time using electrospray ionization mass spectroscopy. The glycosides form a complex in a 1: 1 molar ratio. The influence of the complex on Avena sativa seeds germination and its ichthyotoxicity against Poecilia reticulata were studied.