Russian Journal of Bioorganic Chemistry

, Volume 40, Issue 7, pp 737–741 | Cite as

Molecular complexes of ivy and licorice saponins with sildenafil citrate (Viagra) and their biological activity

  • L. A. Yakovishin
  • A. V. Lekar
  • E. V. Vetrova
  • N. I. Borisenko
  • S. N. Borisenko
  • V. I. Grishkovets
Low-Molecular-Weight Compounds


The molecular complexation of triterpene glycosides α-hederin (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranoside), hederasaponin C (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(l → 4)-O-β-D-glucopyranosyl-(l → 6)-O-β-D-glucopyranoside), and glycyram (monoammonium glycyrrhizinate) with sildenafil citrate was investigated for the first time using electrospray ionization mass spectroscopy. The glycosides form a complex in a 1: 1 molar ratio. The influence of the complex on Avena sativa seeds germination and its ichthyotoxicity against Poecilia reticulata were studied.


triterpene glycosides α-hederin hederasaponin C glycyram sildenafil citrate molecular complex mass spectroscopy ichthyotoxicity allelopathic activity 


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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • L. A. Yakovishin
    • 1
  • A. V. Lekar
    • 2
  • E. V. Vetrova
    • 2
  • N. I. Borisenko
    • 3
  • S. N. Borisenko
    • 2
  • V. I. Grishkovets
    • 4
  1. 1.Sevastopol National Technical UniversitySevastopolUkraine
  2. 2.Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia
  3. 3.Ecological and Analytical CenterSouthern Federal UniversityRostov-on-DonRussia
  4. 4.Vernadsky Taurida National UniversitySimferopolUkraine

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