Skip to main content

In vitro study of the anti-inflammatory activity of some medicinal and edible plants growing in Russia

Abstract

The effects of the ethanolic extracts of 105 plants used in Russian traditional medicine, 26 vegetables and fruits and 2 mushrooms on the release of tumor necrosis factor α (TNF-α) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated differentiated human acute monocytic leukemia THP-1 cells were studied using TNF-α and PGE2 assays, respectively. We found that 16 plant extracts inhibited TNF-α production and 15 extracts decreased PGE2 release in the cells in a concentration-dependent manner. Guilder rose, tansy, shrubby cinquefoil, wintergreen, and prince’s pine, the last two of which belong to the Pyrolaceae family, notably inhibited the levels of both of the inflammatory mediators.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Medzhitov, R., Nature, 2008, vol. 454, pp. 428–435.

    CAS  PubMed  Article  Google Scholar 

  2. 2.

    Allam, R. and Anders, H.J., Curr. Opin. Rheumatol, 2008, vol. 20, pp. 538–544.

    CAS  PubMed  Article  Google Scholar 

  3. 3.

    Uchida, K., Molecules Cells, 2008, vol. 25, pp. 347–351.

    CAS  PubMed  Google Scholar 

  4. 4.

    Lin, W.J. and Yeh, W.C., Shock, 2005, vol. 24, pp. 206–209.

    CAS  PubMed  Article  Google Scholar 

  5. 5.

    Makarov, S.S., Mol. Med. Today, 2000, vol. 6, pp. 441–448.

    CAS  PubMed  Article  Google Scholar 

  6. 6.

    Goldberg, R.B., J. Clin. Endocrinol. Metab., 2009, vol. 94.

  7. 7.

    Martel-Pelletier, J., Pelletier, J.P., and Fahmi, H., Semin. Arthritis Rheumatism, 2003, vol. 33, pp. 155–167.

    CAS  Article  Google Scholar 

  8. 8.

    Hla, T. and Neilson, K., Proc. Natl. Acad. Sci. USA, 1992, vol. 89, no. 16, pp. 7384–7388.

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  9. 9.

    Yamada, M., Niki, H., Yamashita, M., Mue, S., and Ohuchi, K., J. Pharmacol. Exp. Ther., 1997, vol. 281.

  10. 10.

    Iwalewa, E.O., McGaw, L.J., Naidoo, V., and Eloff, J.N., Afr. J. Biotechnol., 2007, vol. 6, pp. 2868–2885.

    CAS  Google Scholar 

  11. 11.

    Garret, A. and FitzGerald, M.D., New England J. Med., 2004, vol. 351, pp. 1709–1711.

    Article  Google Scholar 

  12. 12.

    Chainani-Wu, N., J. Altern. Complement. Med., 2003, vol. 9, pp. 161–168.

    PubMed  Article  Google Scholar 

  13. 13.

    Aggarwal, B.B. and Shishodia, S., Biochemical Pharmacology, 2006, vol. 71, pp. 1397–1421.

    CAS  PubMed  Article  Google Scholar 

  14. 14.

    Kong, D.X., Li, X.J., and Zhang, H.Y., Drug Discov. Today, 2008, vol. 14, pp. 115–119.

    PubMed  Article  Google Scholar 

  15. 15.

    Ivanov, S.A., Nomura, K., Malfanov, I.L., Sklyar, I.V., and Ptitsyn, L.R., Fitoterapia, 2011, vol. 82, pp. 212–218.

    CAS  PubMed  Article  Google Scholar 

  16. 16.

    Tsuchiya, S., Yamabe, M., Yamaguchi, Y., Kobayashi, Y., Konno, T., and Tada, K., Int. J. Cancer, 1980, vol. 26, pp. 171–176.

    CAS  PubMed  Article  Google Scholar 

  17. 17.

    Park, E.K., Jung, H.S., Yang, H.I., Yoo, M.C., Kim, C., and Kim, K.S., Inflam. Res., 2007, vol. 56, pp. 45–50.

    CAS  Article  Google Scholar 

  18. 18.

    Li, G., Liu, Y., Tzeng, N.S., Cui, G., Block, M.L., Wilson, B., Qin, L., Wang, T., Liu, B., Liu, J., and Hong, J.S., Biochem. Pharmacol., 2005, vol. 69, pp. 233–240.

    CAS  PubMed  Article  Google Scholar 

  19. 19.

    Fitzgerald, G.A. and Patrono, C., New England J. Med., 2001, vol. 345, pp. 433–442.

    CAS  Article  Google Scholar 

  20. 20.

    Dictionary of Chinese Material Medicine, Shanghai: Jiangsu New Medical College, Shanghai Scientific and Technological Publisher, 1977.

  21. 21.

    Li, X., Zhou, Y., Huang, X., He, G., Zhou, S., and Huang, H., Zhong Yao Cai, 1997, vol. 20, pp. 402–406.

    CAS  PubMed  Google Scholar 

  22. 22.

    Kosuge, T., Yokota, M., Sugiyama, K., Mure, T., Yamazawa, H., and Yamamoto, T., Chem. Pharm. Bull., 1985, vol. 33, pp. 5355–5357.

    CAS  PubMed  Article  Google Scholar 

  23. 23.

    Kagawa, K., Tokura, K., Uchida, K., Kakushi, H., Shike, T., and Nakai, H., Chem. Pharm. Bull., 1992, vol. 40, pp. 2083–2087.

    CAS  PubMed  Article  Google Scholar 

  24. 24.

    Sur, R., Martin, K., Liebel, F., Lyte, P., Shapiro, S., and Southall, M., Inflammopharmacology, 2009, vol. 17, pp. 42–49.

    CAS  PubMed  Article  Google Scholar 

  25. 25.

    Schinella, G.R., Giner, R.M., and Recio, M.C., Mordujovich de Buschiazzo, P., Rios, J.L., and Máñez, S., J. Pharm. Pharmacol., 1998, vol. 50, pp. 1069–1074.

    CAS  PubMed  Article  Google Scholar 

  26. 26.

    Cam, M., Hisil, Y., and Kuscu, A., Chem. Nat. Comp., 2007, vol. 43.

  27. 27.

    Turek, S. and Cisowski, W., Acta Poloniae Pharmaceutica. Drug Res., 2007, vol. 4, pp. 377–383.

    Google Scholar 

  28. 28.

    Dueñas, M., Sun, B., Hernández, T., Estrella, I., and Spranger, M.I., J. Agricult. Food Chem., 2003, vol. 51, pp. 7999–8004.

    Article  Google Scholar 

  29. 29.

    Benedec, D., Parvu, A.E., Oniga, I., Toiu, A., and Tiperciuc, B., Revista Medicochirurgicala a Societatii de Medici si Naturalisti din Iasi, 2007, vol. 111, pp. 1065–1069.

    Google Scholar 

  30. 30.

    Yu, S., Weaver, V., Martin, K.I., and Cantorna, M.T., BMC Immunol., 2009, vol. 10, no. 12, pp. 1–13.

    Google Scholar 

  31. 31.

    Bralley, E.E., Greenspan, P., Hargrove, J.L., Wicker, L., and Hartle, D.K., J. Inflam., 2008, vol. 5, no. 1, pp. 1–7.

    Article  Google Scholar 

  32. 32.

    Li, H.L., Chen, H.L., Li, H., Zhang, K.L., Chen, X.Y., Wang, X.W., Kong, Q.Y., and Liu, J., Int. J. Mol. Med., 2005, vol. 16, pp. 41–47.

    CAS  PubMed  Article  Google Scholar 

  33. 33.

    Mazid, M.A., Datta, B.K., Bachar, S.C., Bashar, S.A., Nahar, L., and Sarker, S.D., Pharm. Biol., 2010, vol. 48, pp. 770–774.

    PubMed  Article  Google Scholar 

  34. 34.

    Zhang, Y.Z., Shen, J.F., Xu, J.Y., Xiao, J.H., and Wang, J.L., J. Asian Nat. Products Res., 2007, vol. 9, pp. 355–363.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to L. R. Ptitsyn.

Additional information

The article is published in the original.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kalinkevich, K., Karandashov, V.E. & Ptitsyn, L.R. In vitro study of the anti-inflammatory activity of some medicinal and edible plants growing in Russia. Russ J Bioorg Chem 40, 752–761 (2014). https://doi.org/10.1134/S106816201407005X

Download citation

Keywords

  • anti-inflammatory
  • plant extracts
  • TNF-α assay
  • PGE2 assay