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The search of novel inhibitors of HIV-1 integrase among 5-(4-halogenophenyl)-5-oxopentyl derivatives of nucleic bases

Abstract

New nucleic base derivatives were obtained by alkylation of uracil, thymine, cytosine, adenine, 6-chloropurine, and 2-amino-6-chloropurine with 5-chloro-1-(4-halogenophenyl)-1-pentanones, and their physical and chemical properties were studied. The influence of the compounds synthesized on the HIV-1 integrase activity was studied.

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Abbreviations

DBU:

1,8-diazabicyclo[5.4.0]undec-7-ene

HIV-1:

human immunodeficiency virus type 1

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Correspondence to A. M. Kritzyn.

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Original Russian Text © V.V. Komissarov, E.S. Knyazhanskaya, A.V. Atrokhova, M.B. Gottikh, A.M. Kritzyn, 2014, published in Bioorganicheskaya Khimiya, 2014, Vol. 40, No. 5, pp. 578–587.

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Komissarov, V.V., Knyazhanskaya, E.S., Atrokhova, A.V. et al. The search of novel inhibitors of HIV-1 integrase among 5-(4-halogenophenyl)-5-oxopentyl derivatives of nucleic bases. Russ J Bioorg Chem 40, 532–540 (2014). https://doi.org/10.1134/S1068162014050094

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  • DOI: https://doi.org/10.1134/S1068162014050094

Keywords

  • alkylation
  • HIV-1integrase
  • nucleosides
  • polymethylene analogues