Skip to main content

Androgenic-anabolic activities of some new synthesized steroidal pyrane, pyridine, and thiopyrimidine derivatives

Abstract

In continuation of our previous work, fused steroidal derivatives with pyrane, pyridine, pyrimidine moieties were synthesized and evaluated as androgenic-anabolic agents. Some of the newly synthesized compounds are exhibited pronounced androgenic-anabolic activities.

This is a preview of subscription content, access via your institution.

References

  1. Amr, A.E. and Abdulla, M.M., Indian J. Heterocycl. Chem., 2002, vol. 12, pp. 129–134.

    CAS  Google Scholar 

  2. Amr, A.E., Abdel-Latif, N.A., and Abdalla, M.M., Bioorg. Med. Chem., 2006, vol. 14, pp. 373–384.

    Article  CAS  Google Scholar 

  3. Abdulla, M.M., Amr, A.E., Al-Omar, M.A., Hussain, A.A., and Shalaby, A.F.A., Life Sci. J., 2013, vol. 10, pp. 286–229.

    Google Scholar 

  4. Abdulla, M.M., Al-Omar, M.A., and Amr, A.E., Life Sci. J., 2013, vol. 10, pp. 327–335.

    Google Scholar 

  5. Abdulla, M.M.. Amr, A.E., Al-Omar, M.A., Hussain, A.A. and Amer, M.S., Life Sci. J., 2013, vol. 10, pp. 351–361.

    Google Scholar 

  6. Abdulla, M.M., Amr, A.E., Al-Omar, M.A., Hussain, A.A., and Amer M.S., Life Sci. J., 2013, vol. 10, pp. 599–607.

    Google Scholar 

  7. Lavery, D.N. and McEwan, I.J., Biochem. J., 2005, vol. 391, pp. 449–464.

    PubMed  Article  CAS  PubMed Central  Google Scholar 

  8. Cheskis, B., J. Cell. Biochem., 2004, vol. 93, pp. 20–27.

    PubMed  Article  CAS  Google Scholar 

  9. Roselli, C.E., Brain Res., 1998, vol. 792, pp. 271–276.

    PubMed  Article  CAS  Google Scholar 

  10. Brodsky, I., Balagopal, P., and Nair, K, J. Clin. Endocrinol. Metab., 1996, vol. 81, pp. 3469–3475.

    PubMed  CAS  Google Scholar 

  11. Hickson, R., Czerwinski, S., Falduto, M., and Young, A., Med. Sci. Sports Exerc., 1990, vol. 22, pp. 331–340.

    PubMed  Article  CAS  Google Scholar 

  12. Singh, R., Artaza, J., Taylor, W., Gonzalez-Cadavid, N., and Bhasin, S., Endocrinology, 2003, vol. 144, pp. 5081–5088.

    PubMed  Article  CAS  Google Scholar 

  13. Brinkmann, A.O., Faber, P.W., van Rooij, H.C., Kuiper, G.G., Ris, C., Klaassen, P., van der Korput, J.A., Voorhorst, M.M., van Laar, J.H., Mulder, E., et al., J. Steroid. Biochem., 1989, vol. 34, pp. 307–310.

    PubMed  Article  CAS  Google Scholar 

  14. Hershberger, L.G., Shipley, E.G. and Meyer, R.K., Proc. Soc. Exp. Biol. Med., 1953, vol. 83, pp. 175–180.

    PubMed  Article  CAS  Google Scholar 

  15. Kuhnz, W. and Beier, S., Contraception, 1994, vol. 49, pp. 275–289.

    PubMed  Article  CAS  Google Scholar 

  16. Austen, K. F. and Brocklehurst, W. E., J. Exp. Med., 1961, vol. 113, pp. 521–539.

    PubMed  Article  CAS  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Abd El-Galil E. Amr.

Additional information

The article is published in the original.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Abdalla, M.M., Amr, A.EG.E., Al-Omar, M.A. et al. Androgenic-anabolic activities of some new synthesized steroidal pyrane, pyridine, and thiopyrimidine derivatives. Russ J Bioorg Chem 40, 568–578 (2014). https://doi.org/10.1134/S106816201405001X

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S106816201405001X

Keywords

  • steroidal derivatives
  • pyranes
  • pyridines
  • pyrimidines
  • androgenic-anabolic activities