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Molecular model of anthrax toxin translocation into the target cells

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Abstract

Molecular mechanism of receptor-mediated endocytosis for binary toxins is proposed in this publication. According to this mechanism effector oligomeric complex with common structure 7A + 7B* (but not separated A subunits) penetrates into target cells. Molecular weight of this complex is 750 kDa for Anthrax Toxin.

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Abbreviations

PA:

protective antigen

LF and EF:

lethal and edema factors

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Authors and Affiliations

  1. Clostridiosis Laboratory, Department of Bacteriology, Gamaleya Institute of Epidemiology and Microbiology, ul. Gamalei 18, 123098, Moscow, Russia

    A. N. Noskov

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  1. A. N. Noskov
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Original Russian Text © A.N. Noskov, 2014, published in Bioorganicheskaya Khimiya, 2014, Vol. 40, No. 4, pp. 399–404.

The article was translated by the authors.

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Noskov, A.N. Molecular model of anthrax toxin translocation into the target cells. Russ J Bioorg Chem 40, 370–374 (2014). https://doi.org/10.1134/S1068162014040098

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  • DOI: https://doi.org/10.1134/S1068162014040098

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