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Synthesis and evaluation of novel 6-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents

Abstract

A novel series of uracil derivatives with a 3,5-dimethylbenzyl group at the C-6 position were synthesized and evaluated as non-nucleoside HIV-1 reverse transcriptase inhibitors. Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. Some of the tested compounds showed moderate to potent activities against wildtype HIV-1, and N-1 alkylated derivatives were highly active.

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Correspondence to Nagy M. Khalifa.

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Khalifa, N.M., Pedersen, E.B., Nielsen, C. et al. Synthesis and evaluation of novel 6-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents. Russ J Bioorg Chem 40, 579–585 (2014). https://doi.org/10.1134/S1068162014040050

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  • DOI: https://doi.org/10.1134/S1068162014040050

Keywords

  • HIV-1 RT
  • S-DABOs analogues
  • HEPTs analogues
  • anti HIV-1 activity