Skip to main content

Synthesis, isomerism, and hypotensive activity of thiethane-containing hydrazones of uracilylacetic acid


By the reaction of 2-[6-methyl-1-(thiethane-3-yl)uracil-3-yl]acetic acid hydrazide with aryl aldehydes and acetophenone derivatives, acylhydrazones have been obtained, which exist in DMSO solutions as a mixture of two stereoisomers of an E C=N-isomer, due to the hindered internal rotation around the hydrazide bond. It has been found that the compounds synthesized exhibit a hypotensive activity.

This is a preview of subscription content, access via your institution.



arterial hypertension


arterial pressure


systolic arterial pressure


heart rate


  1. Erbel, R., Lehmann, N., Mohlenkamp, S., Churzidse, S., Bauer, M., Kalsch, H., Schmermund, A., Moebus, S., Stang, A., Roggenbuck, U., Brocker-Preuss, M., Dragano, N., Weimar, C., Siegrist, J., and Jockel, K.H., Hypertension, 2012, vol. 59, pp. 44–53.

    CAS  PubMed  Article  Google Scholar 

  2. Yoon, S.S., Ostchega, Y., and Louis, T., NCHS Data Brief, 2010, vol. 48, pp. 1–8.

    PubMed  Google Scholar 

  3. Yakovleva, T.V., Proc. 9th All-Russia. Congr. “Hypertension: Yesterday, Today and Tomorrow,” Ivanovo, 1997.

    Google Scholar 

  4. Ministry of Healthcare of the Russian Federation Report “Operational Data on the Natural Movement of the Population of the Russian Federation in May 2012.” 2012-05

  5. Chazova, I.E., Chuchalin, A.G., Zykov, K.A., and Ratova, L.G., Sist. Gipertenzii, 2013, no. 1, p. 5.

    Google Scholar 

  6. Morozova, T.E. and Andrushchishina, T.B., Lechashchii Vrach, 2013, no. 2, pp. 7–9.

    Google Scholar 

  7. Oganov, R.G., Pogosova, G.N., Koltunov, I.E., Irdzevskaya, V.P., Sokolova, O.Y., and Vigodin, V.A., Eur. J. Cardiovasc. Prev. Rehabil., 2011, vol. 18, pp. 224–232.

    PubMed  Article  Google Scholar 

  8. Sturov, N.V. and Kuznetsov, V.I., Zemskii Vrach, 2010, no. 1, pp. 15–18.

    Google Scholar 

  9. Block, E., Comp. Heterocyclic Chem., 1997, vol. 7, pp. 403–410.

    Google Scholar 

  10. Kataev, V.A., Meshcheryakova, S.A., Lazarev, V.V., and Kuznetsov, V.V., Zh. Org. Khim., 2013, vol. 49, pp. 761–762.

    Google Scholar 

  11. Meshcheryakova, S.A. and Kataev, V.A., Zh. Org. Khim., 2013, vol. 49, pp. 1373–1375.

    Google Scholar 

  12. Flegontov, S.A., Titova, Z.S., Buzykin, B.I., and Kitaev, Yu.P., Izv. Akad. Nauk SSSR, Ser. Khim., 1977, no. 2, pp. 335–339.

    Google Scholar 

  13. Kuba, E.P., Tetrahedron Lett., 1973, p. 5117.

    Google Scholar 

  14. Zelenin, K.N., Pinson, V.V., Potekhin, A.A., Bezhan, I.P., Khrustalev, V.A., and Lobanov, P.S., Zh. Org. Khim., 1978, vol. 14, pp. 490–495.

    CAS  Google Scholar 

  15. Rutavichyus, A., Valyulene, S., and Kuodis, Z., Khim. Geterotsikl. Soedin., 2000, no. 7, pp. 966–971.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to V. N. Perfilova.

Additional information

Original Russian Text © S.A. Meshcheryakova, V.A. Kataev, K.V. Nikolaeva, V.N. Perfilova, D.D. Borodin, I.N. Tyurenkov, 2014, published in Bioorganicheskaya Khimiya, 2014, Vol. 40, No. 3, pp. 327–334.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Meshcheryakova, S.A., Kataev, V.A., Nikolaeva, K.V. et al. Synthesis, isomerism, and hypotensive activity of thiethane-containing hydrazones of uracilylacetic acid. Russ J Bioorg Chem 40, 300–307 (2014).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • uracil
  • thiethane
  • acylhydrazones
  • E,Z-isomers
  • hypotensive activity