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Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives

Russian Journal of Bioorganic Chemistry volume 40, pages 336–342 (2014)Cite this article

Abstract

This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H NMR and 13C NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.

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Authors and Affiliations

  1. Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdoǧan University, Rize, Turkey

    E. Menteşe, F. Yılmaz & N. Karaali

  2. Department of Biology, Faculty of Arts and Sciences, Recep Tayyip Erdoǧan University, Rize, Turkey

    S. Ülker

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey

    B. Kahveci

Authors
  1. E. Menteşe
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  2. F. Yılmaz
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  3. N. Karaali
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  4. S. Ülker
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  5. B. Kahveci
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Correspondence to E. Menteşe.

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Menteşe, E., Yılmaz, F., Karaali, N. et al. Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives. Russ J Bioorg Chem 40, 336–342 (2014). https://doi.org/10.1134/S1068162014030091

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  • DOI: https://doi.org/10.1134/S1068162014030091

Keywords

  • benzimidazole
  • perimidine
  • bisbenzimidazole
  • microwave synthesis
  • iminoester hydrochloride
  • lipase inhibition