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Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives

Abstract

This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H NMR and 13C NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.

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Correspondence to E. Menteşe.

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Menteşe, E., Yılmaz, F., Karaali, N. et al. Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives. Russ J Bioorg Chem 40, 336–342 (2014). https://doi.org/10.1134/S1068162014030091

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  • DOI: https://doi.org/10.1134/S1068162014030091

Keywords

  • benzimidazole
  • perimidine
  • bisbenzimidazole
  • microwave synthesis
  • iminoester hydrochloride
  • lipase inhibition