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A green synthetic approach to the synthesis of Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile as potential anti-inflammatory agents

Abstract

A green, novel, rapid, and efficient protocol is developed for the synthesis of various Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile using ammonium chloride as a very inexpensive and readily available reagent in refluxing ethanol. High yields, easy work-up, and short reaction times are advantages of this environmentally benign procedure. The prepared compounds were screened for their anti-inflammatory activity “at a dose of 10 mg/kg body weight,” which revealed promising activities relative to indomethacin used as a reference standard in this study.

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Correspondence to E. M. Hussein.

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Abdel-Mohsen, S.A., Hussein, E.M. A green synthetic approach to the synthesis of Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile as potential anti-inflammatory agents. Russ J Bioorg Chem 40, 343–349 (2014). https://doi.org/10.1134/S1068162014030029

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  • DOI: https://doi.org/10.1134/S1068162014030029

Keywords

  • green synthesis
  • Schiff bases
  • anti-inflammatory
  • rapid procedure
  • 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile