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Antioxidant properties of conjugates of polyethylene glycols containing terpenophenolic fragments

Abstract

A series of water-soluble conjugates has been synthesized from polyethylene glycols of various lengths and 4-bromomethyl-2,6-diisobornylphenol. The membrane protective and antioxidant activities of the synthesized products were evaluated on the model of the H2O2-induced hemolysis of erythrocytes. It was shown that the studied conjugates have a significant antioxidant activity, and a significant membrane protective effect was shown for the conjugates containing 0.2% and 0.8% of the 2,6-diisobornyl-4-methylenephenolic fragments.

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Abbreviations

PEG:

polyethylene glycol

LPO:

lipid peroxidation

TBA-RS:

products reacting with 2-thiobarbituric acid (TBA-reactive substances)

oxyHb:

oxyhemoglobin

metHb:

methemoglobin

ferrylHb:

ferrylhemoglobin

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Correspondence to E. V. Buravlev.

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Original Russian Text © I.Yu. Chukicheva, M.A. Torlopov, E.V. Buravlev, O.G. Shevchenko, A.V. Kuchin, 2014, published in Bioorganicheskaya Khimiya, 2014, Vol. 40, No. 1, pp. 85–91.

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Chukicheva, I.Y., Torlopov, M.A., Buravlev, E.V. et al. Antioxidant properties of conjugates of polyethylene glycols containing terpenophenolic fragments. Russ J Bioorg Chem 40, 76–81 (2014). https://doi.org/10.1134/S1068162014010026

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  • DOI: https://doi.org/10.1134/S1068162014010026

Keywords

  • polyethylene glycols
  • terpenophenols
  • antioxidants
  • membrane protective properties
  • red blood cells
  • oxidative hemolysis