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Isolation of pomolic acid from Chamaenerion angustifolium and the evaluation of its potential genotoxicity in bacterial test systems

Abstract

The lipophilic components of the medicinal plant, the fireweed (Chamaenerion angustifolium), have been examined using the raw materials of a three-year harvest. Twenty eight aliphatic and six triterpene acids have been detected for the first time by chromatography—mass spectrometry analysis. It has been shown using the Ames test and the SOS chromotest that pomolic acid possesses no genotoxic and mutagenic properties.

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Abbreviations

C-MS:

chromatography—mass spectrometry

MTBE:

methyl tert-butyl ester

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Correspondence to T. S. Frolova.

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Original Russian Text © T.S. Frolova, O.I. Sal’nikova, T.A. Dudareva, T.P. Kukina, O.I. Sinitsyna, 2014, published in Bioorganicheskaya Khimiya, 2014, Vol. 40, No. 1, pp. 92–98.

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Frolova, T.S., Sal’nikova, O.I., Dudareva, T.A. et al. Isolation of pomolic acid from Chamaenerion angustifolium and the evaluation of its potential genotoxicity in bacterial test systems. Russ J Bioorg Chem 40, 82–88 (2014). https://doi.org/10.1134/S1068162013060046

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  • DOI: https://doi.org/10.1134/S1068162013060046

Keywords

  • fireweed
  • pomolic acid
  • bacterial test systems