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Eco-friendly synthesis and in vitro antibacterial activities of some novel chalcones

Abstract

Chalcone derivatives have been synthesized by reaction of 1-(2,5-dimethyl-furan-3-yl)-ethanone with corresponding active aldehyde in ethanolic NaOH in microwave oven. The structure of these compounds was established by elemental analysis, IR, 1H NMR, 13C NMR, and EI-MS spectral analysis. The anti-bacterial activity of these compounds was first tested in vitro by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug chloramphenicol. The results showed that pyrazol containing chalcone (compound 8) inhibited both types of bacteria (Gram-positive and Gram-negative) better than chloramphenicol.

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Correspondence to Salman A. Khan.

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Khan, S.A., Asiri, A.M., Alamry, K.A. et al. Eco-friendly synthesis and in vitro antibacterial activities of some novel chalcones. Russ J Bioorg Chem 39, 312–317 (2013). https://doi.org/10.1134/S1068162013030072

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  • DOI: https://doi.org/10.1134/S1068162013030072

Keywords

  • chalcones
  • anti-bacterial activity
  • chloramphenicol