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Russian Journal of Bioorganic Chemistry

, Volume 38, Issue 3, pp 328–334 | Cite as

Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives

  • Chan Woo Lee
  • Nok Hyun Park
  • Jin Woong KimEmail author
  • Byung Hun Um
  • A. V. Shpatov
  • E. E. Shults
  • I. V. Sorokina
  • S. A. PopovEmail author
Article

Abstract

Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).

Keywords

collagenase-1 triterpenoids dihydroquercetin photoageing interleukin-8 

Abbreviations

MMP-1

matrix metalloproteinase-1; collagenase-1

IL-8

Interleukin-8

DMEM

Dulbecco’s modified Eagle’s medium

FBS

fetal bovine serum

PBS

phosphate buffered saline

HaCaT cells

Immortalized human Keratinocytes

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • Chan Woo Lee
    • 1
  • Nok Hyun Park
    • 1
  • Jin Woong Kim
    • 2
    Email author
  • Byung Hun Um
    • 3
  • A. V. Shpatov
    • 4
  • E. E. Shults
    • 4
  • I. V. Sorokina
    • 4
  • S. A. Popov
    • 4
    Email author
  1. 1.Amore-Pacific Co. R&D CenterGyeonggi-DoRepublic of Korea
  2. 2.Dept. of Applied ChemistryHanyang UniversityKyeonggi-doRepublic of Korea
  3. 3.Natural Products Research CenterKorea Institute of Science and Technology (KIST) Gangneung InstituteGangwon-doRepublic of Korea
  4. 4.Novosibirsk Institute of Organic ChemistryNovosibirskRussian Federation

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