Enzymatic activity of thymidine kinases of a herpes simplex virus strains resistant to acyclovir H-phosphonates

  • A. A. Gus’kova
  • M. Yu. Skoblov
  • V. L. Andronova
  • G. A. Galegov
  • S. N. Kochetkov
  • Yu. S. Skoblov


Some cloned laboratory mutant strains of herpes simplex virus type I resistant to acyclovir H-phosphonate were studied. As was shown for all the clones, the mutations augmented the susceptibility to cidîfovir. Thymidine kinase of the mutant viruses partially retained the capacity to phosphorylate thymidine, but lost the capacity to phosphorylate BVDU.


thymidine kinase herpes simplex virus type I 



acyclovir or (9-[(hydroxyethyl)methyl]guanine




acyclovir H-phosphonate




herpes simplex virus type 1


plaque-forming unit


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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • A. A. Gus’kova
    • 1
  • M. Yu. Skoblov
    • 1
  • V. L. Andronova
    • 2
  • G. A. Galegov
    • 2
  • S. N. Kochetkov
    • 3
  • Yu. S. Skoblov
    • 4
  1. 1.Research Center for Medical GeneticsRussian Academy of Medical SciencesMoscowRussia
  2. 2.Ivanovskii Institute of VirologyRussian Academy of Medical SciencesMoscowRussia
  3. 3.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia
  4. 4.Shemyakin-Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia

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