Skip to main content
SpringerLink
Log in

Synthesis of cationic alkyl glycerolipids with heterocyclic nitrogen-containing bases as polar domains

  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract

Synthesis of new cationic alkyl glycerolipids with potential antitumor properties is described, their polar domain being heterocyclic nitrogen-containing bases of various types. A synthetic scheme for cationic lipids containing aliphatic short-chain substituents in the heterocyclic polar head is proposed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Plyavnik, N.V., Shtil, A.A., and Serebrennikova, G.A., Mini-Rev. Med. Chem., 2006, pp. 533–542.

  2. Ruiter, G.A., Verheij, M., Zerp, S.F., and van Blitterswijk, W.J., I. J. Radiat. Biol. Phys., 2001, vol. 49, pp. 415–419.

    Article  CAS  Google Scholar 

  3. Mollinedo, F., Gajate, C., Martin-Santamaria, S., and Gago, F., Curr. Med. Chem., 2004, vol. 11, pp. 3163–3184.

    PubMed  CAS  Google Scholar 

  4. Jendrossek, V. and Handrick, R., Curr. Med. Chem. Anti-Cancer Agents, 2003, vol. 3, pp. 343–353.

    Article  CAS  Google Scholar 

  5. Ausisi, A., Torrecillas, A., Aranda, F.J., Mollinedo, F., Gajate, C., Corbalan-Garcia, S., de Godos, A., and Gomez-Fernandez, J.C., J. Phys. Chem., 2008, vol. 112, pp. 11643–11654.

    Google Scholar 

  6. Gajate, C. and Mollinedo, F., Curr. Drug Metab., 2002, vol. 3, pp. 491–495.

    Article  PubMed  CAS  Google Scholar 

  7. Heczkova, B. and Slotte, J.P., FEBS Lett., 2006, vol. 580, pp. 2471–2476.

    Article  PubMed  CAS  Google Scholar 

  8. Mollinedo, F., Fernandez-Luna, J.L., Gajate, C., Martin-Martin, B., Benito, A., Martinez-Dalmau, R., and Modolell, M., Cancer Res., 1997, vol. 57, pp. 1320–1328.

    PubMed  CAS  Google Scholar 

  9. Romanova, S.G., Romanov, V.G., Serebrennikova, G.A., and Shtil’, A.A., Biomed. Khim., 2010, vol. 56, pp. 457–470.

    PubMed  CAS  Google Scholar 

  10. Gajate, C. and Mollinedo, F., Blood, 2007, vol. 109, pp. 711–719.

    Article  PubMed  CAS  Google Scholar 

  11. Romanova, S.G., Romanov, V.G., Plyavnik, N.V., Serebrennikova G A., and Shtil’ A.A, Vestnik MITKhT, 2008, vol. 3, pp. 53–57.

    Google Scholar 

  12. Plyavnik, N.V., Maslov, M.A., and Serebrennikova, G.A., Bioorg. Khim., 2004, vol. 30, pp. 507–511 [Russ. J. Bioorg. Chem. (Engl. Transl.), 2004, vol. 30, pp. 454–458].

    Google Scholar 

  13. Romanova, S.G., Shtil’, A.A., and Serebrennikova, G.A., Bioorg. Khim., 2008, vol. 34, pp. 827–830 [Russ. J. Bioorg. Chem. (Engl. Transl.), 2008, vol. 34, pp. 743–746].

    PubMed  CAS  Google Scholar 

  14. Koufaki, M., Polychroniou, V., Calogeropoulou, T., Tsotinis, A., Drees, M., Fiebig, H.H., LeClerc, S., Hendriks, H.R., and Makriyannis, A., J. Med. Chem., 1996, vol. 39, pp. 2609–2614.

    Article  PubMed  CAS  Google Scholar 

  15. Markova, A.A., Plyavnik, N.V., Tatarskii, V.V., Jr., Shtil’, A.A., and Serebrennikova, G.A., Bioorg. Khim., 2010, vol. 36, pp. 574–576 [Russ. J. Bioorg. Chem. (Engl. Transl.), 2010, vol. 36, pp. 532–534].

    PubMed  CAS  Google Scholar 

  16. Papazari, P., Avlonitis, N., Angelou, P., Calogeropoulou, T., Koufaki, M., Scoulica, E., and Fragiadaki, I., Cancer Chemother. Pharmacol., 2005, vol. 56, pp. 261–270.

    Article  Google Scholar 

  17. Plyavnik, N.V., Maslov, M.A., and Serebrennikova, G.A., Izv. Ross. Acad. Nauk, Ser. Khim., 2008, no. 11, pp. 2148–2151.

  18. Maslov, M.A., Sycheva, E.V., Morozova, N.G., and Serebrennikova, G.A., Izv. Ross. Acad. Nauk, Ser. Khim., 1999, no. 7, pp. 1381–1384.

Download references

Author information

Authors and Affiliations

  1. Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, 119571, Moscow, Russia

    N. V. Plyavnik, T. V. Kramareva & G. A. Serebrennikova

Authors
  1. N. V. Plyavnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. V. Kramareva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. A. Serebrennikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. V. Plyavnik.

Additional information

Original Russian Text © N.V. Plyavnik, T.V. Kramareva, G.A. Serebrennikova, 2011, published in Bioorganicheskaya Khimiya, 2011, Vol. 37, No. 4, pp. 552–558.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Plyavnik, N.V., Kramareva, T.V. & Serebrennikova, G.A. Synthesis of cationic alkyl glycerolipids with heterocyclic nitrogen-containing bases as polar domains. Russ J Bioorg Chem 37, 492–498 (2011). https://doi.org/10.1134/S1068162011040108

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162011040108

Keywords

Search

Navigation