Abstract
The small regulatory non-coding RNA molecules, known as microRNAs (miRNAs), have been recognized as potential regulator of gene expression and modulate the gene function at the post-transcriptional level. It is now clear that miRNA biogenesis and function are related to the molecular mechanisms of various clinical diseases, which can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death viral infection and tumorgenesis. Here, we review recent work and provide insight into the diverse roles of miRNAs.
Similar content being viewed by others
References
Guarnieri, D.J. and DiLeone, R.J., Ann Med., 2008, vol. 2, pp. 197–208.
Bartel, D.P., Cell, 2009, vol. 136, pp. 215–233.
Lee, R.C., Feinbaum, R.L., and Ambros, V., Cell, 1993, vol. 75, pp. 843–854.
Wightman, B., Ha, I., and Ruvkun, G., Cell, 1993, vol. 75, pp. 855–862.
Olsen, P.H., and Ambros, V., Dev. Biol., 1999, vol. 216, pp. 671–680.
Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R., and Ruvkun, G., Nature, 2000, vol. 403, pp. 901–906.
Krek, A., Grun, D., Poy, M.N., Wolf, R., Rosenberg, L., Epstein, E.J., MacMenamin, P., da Piedade, I., Gunsalus, K.C., Stoffel, M., and Rajewsky, N., Nat. Genet., 2005, vol. 37, pp. 495–500.
Seitz, H. and Zamore, P.D., Cell, 2006, vol. 125, pp. 827–829.
Liu, X., Luo, G., Bai, X., and Wang, X.J.J., Genet. Genomics., 2009, vol. 36, pp. 591–601.
Du, T. and Zamore, P.D., Development, 2005, vol. 132, pp. 4645–4652.
Papp, I., Mette, M.F., Aufsatz, W., Daxinger, L., Schauer, S.E., Ray, A., van der Winden, J., Matzke, M., and Matzke, A.J., Plant Physiol., 2003, vol. 132, pp. 1382–1390.
Shomron, N. and Levy, C., J. Biomed. Biotechnol., 2009, vol. 2009, pp. 594–678.
Park, W., Li, J., Song, R., Messing, J., and Chen, X., Curr. Biol., 2002, vol. 12, pp. 1484–1495.
Schratt, G.M., Tuebing, F., Nigh, E.A., Kane, C.G., Sabatini, M.E., Kiebler, M., and Greenberg, M.E., Nature, 2006, vol. 439, pp. 283–289.
Kim, J., Inoue, K., Ishii, J., Vanti, W.B., Voronov, S.V., Murchison, E., Hannon, G., and Abeliovich, A., Science., 2007, vol. 317, pp. 1220–1224.
Sempere, L.F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., and Ambros, V., Genome Biol., 2004, vol. 5, p. R13.
Smirnova, L., Grafe, A., Seiler, A., Schumacher, S., Nitsch, R., and Wulczyn, F.G., Eur. J. Neurosci., 2005, vol. 21, pp. 1469–1477.
Song, L. and Tuan, R.S., Birth. Defects Res. C Embryo Today, 2006, vol. 78, pp. 140–149.
Chen, C.Z., Li, L., Lodish, H.F., and Bartel, D.P., Science, 2004, vol. 303, pp. 83–86.
Johnston, R.J., Hobert, O., Nature, 2003, vol. 426, pp. 845–849.
Bushati, N. and Cohen, S.M., Annu. Rev. Cell Dev. Biol., 2007, vol. 23, pp. 175–205.
Johnston, R.J.J., Chang, S., Etchberger, J.F., Ortiz, C.O., and Hobert, O., Proc. Natl. Acad. Sci. USA, 2005, vol. 102, pp. 1249–1254.
Visvanathan, J., Lee, S., Lee, B., Lee, J.W., and Lee, S.K., Genes Dev., 2007, vol, 21, pp. 744–749.
Coulson, J.M., Curr. Biol., 2005, vol. 15, pp. R665–668.
Shi, Y. and Jin, Y., Sci. China C Life Sci., 2009, vol. 52, pp. 205–211.
Makeyev, E.V., Zhang, J., Carrasco, M.A., and Maniatis, T., Mol. Cell, 2007, vol. 27, pp. 435–448.
Melton, C., Judson, R.L., and Blelloch, R., Nature, 2010, vol. 463, pp. 621–626.
Sugatani, T. and Hruska, K.A., J. Biol. Chem., 2009, vol. 284, pp. 4667–4678.
Zhang, Y., Chao, T., Li, R., Liu, W., Chen, Y., Yan, X., Gong, Y., Yin, B., Qiang, B., Zhao, J., Yuan, J., and Peng, X., J. Mol. Med., 2009, vol. 87, pp. 43–51.
Ivey, K.N., Muth, A., Arnold, J., King, F.W., Yeh, R.F., Fish, J.E., Hsiao, E.C., Schwartz, R.J., Conklin, B.R., Bernstein, H.S., et al., Cell Stem. Cell, 2008, vol. 2, pp. 219–229.
Kiyosawa, K., Sodeyama, T., Tanaka, E., Gibo, Y., Yoshizawa, K., Nakano, Y., Furuta, S., Akahane, Y., Nishioka, K., Purcell, R.H., et al., Hepatology, 1990, vol. 12, pp. 671–675.
Jin, W.B., Wu, F.L., Kong, D., and Guo, A.G., Comput. Biol. Chem., 2007, vol. 31, pp. 124–126.
Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M., and Sarnow, P., Science, 2005, vol. 309, pp. 1577–1581.
Pedersen, I.M., Cheng, G., Wieland, S., Volinia, S., Croce, C.M., Chisari, F.V., and David, M., Nature, 2007, vol. 449, pp. 919–922.
Sonkoly, E., Wei, T., Janson, P.C., Saaf, A., Lundeberg, L., Tengvall-Linder, M., Norstedt, G., Alenius, H., Homey, B., Scheynius, A., Stahle, M., and Pivarcsi, A., PLoS One, 2007, vol. 2, pp. e610.
Chen, T., Huang, Z., Wang, L., Wang, Y., Wu, F., Meng, S., and Wang, C,. Cardiovasc. Res., 2009. vol. 83, p. 131–139.
Wang, S., Aurora, A.B., Johnson, B.A., Qi, X., McAnally, J., Hill, J.A., Richardson, J.A., Bassel-Duby, R., and Olson, E.N., Dev. Cell, 2008, vol. 15, pp. 261–271.
O’Connell, R.M., Rao, D.S., Chaudhuri, A.A., Boldin, M.P., Taganov, K.D., Nicoll, J., Paquette, R.L., and Baltimore, D., J. Exp. Med., 2008, vol. 205, pp. 585–594.
Cordes, K.R., Sheehy, N.T., White, M.P., Berry, E.C., Morton, S.U., Muth, A.N., Lee, T.H., Miano, J.M., Ivey, K.N., and Srivastava, D., Nature, 2009, vol. 460, pp. 705–710.
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., and Tuschl, T., Curr. Biol., 2002, vol. 12, pp. 735–739.
Chan, J.A., Krichevsky, A.M., and Kosik, K.S., Cancer Res., 2005, vol. 65, pp. 6029–6033.
Ciafre, S.A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.G., Sabatino, G., Negrini, M., Maira, G., Croce, C.M., and Farace, M.G., Biochem. Biophys. Res. Commun., 2005, vol. 334, pp. 1351–1358.
Kim, H.J., Kim, Y.H., Lee, D.S., Chung, J.K., and Kim, S., J. Nucl. Med., 2008, vol. 49, pp. 1686–1693.
Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., Mitsudomi, T., and Takahashi, T., Cancer Res., 2004, vol. 64, pp. 3753–3756.
Wurdinger, T., Tannous, B.A., Saydam, O., Skog, J., Grau, S., Soutschek, J., Weissleder, R., Breakefield, X.O., and Krichevsky, A.M., Cancer Cell, 2008, vol. 14, pp. 382–393.
El Ouaamari, A., Baroukh, N., Martens, G.A., Lebrun, P., Pipeleers, D., and van Obberghen, E., Diabetes, 2008, vol. 57, pp. 2708–2717.
Wang, S., Aurora, A.B., Johnson, B.A., Qi, X., McAnally, J., Hill, J.A., Richardson, J.A., Bassel-Duby, R., and Olson, E.N., Dev. Cell, 2008, vol. 15, pp. 261–271.
O’Connell, R.M., Taganov, K.D., Boldin, M.P., Cheng, G., and Baltimore, D., Proc. Natl. Acad. Sci. USA, 2007, vol. 104, pp. 1604–1609.
Isken, F., Steffen, B., Merk, S., Dugas, M., Markus, B., Tidow, N., Zuhlsdorf, M., Illmer, T., Thiede, C., Berdel, W.E., Serve, H., and Muller-Tidow, C. Br., J. Haematol., 2008, vol. 140, pp. 153–161.
Carlsbecker, A., Lee, J.Y., Roberts, C.J., Dettmer, J., Lehesranta, S., Zhou, J., Lindgren, O., Moreno-Risueno, M.A., Vaten, A., Thitamadee, S., Campilho, A., Sebastian, J., Bowman, J.L., Helariutta, Y., and Benfey, P.N., Nature, 2010, doi:10.1038/nature08977.
Tay, Y., Zhang, J., Thomson, A.M., Lim, B., and Rigoutsos, I., Nature, 2008, vol. 455, pp. 1124–1128.
Author information
Authors and Affiliations
Corresponding author
Additional information
The article is published in the original.
Rights and permissions
About this article
Cite this article
Huang, Y., Shen, X.J., Zou, Q. et al. Biological functions of MicroRNAs. Russ J Bioorg Chem 36, 684–689 (2010). https://doi.org/10.1134/S1068162010060026
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1068162010060026