Abstract
A series of novel alkyl cationic glycerolipids with a heterocyclic polar domain have been synthesized. The most reactive compound, rac-N-{4-[(2-ethoxy-3-octadecyloxy)prop-1-yloxycarbonyl]butyl}-N′-ethylimidazolium iodide, at micromolar concentrations induced a delay of the cell cycle in the G1 phase, DNA fragmentation, and the apoptosis of human leukosis cells.
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Original Russian Text © A.A. Markova, N.V. Plyavnik, V.V. Tatarskii Jr., A.A. Shtil, G.A. Serebrennikova, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 4, pp. 574–576.
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Markova, A.A., Plyavnik, N.V., Tatarskii, V.V. et al. Novel alkyl cationic glycerolipids with a heterocyclic polar domain induce disturbances of the cell cycle and the death of human leukemia cells. Russ J Bioorg Chem 36, 532–534 (2010). https://doi.org/10.1134/S106816201004014X
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DOI: https://doi.org/10.1134/S106816201004014X