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Synthesis and properties of myelopeptides possessing differentiating activity

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Abstract

Bone marrow peptides Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro (MP-4) and Val-Asp-Pro-Pro (MP-6) have been synthesized by the classical and solid-phase methods of peptide chemistry, and their differentiating activity has been studied on leukemia cell lines HL-60 and K-562. It has been shown that both peptides induce the terminal differentiation of leukemic blasts; however, their mechanisms of action are different.

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Abbreviations

Bzl:

benzyl

BSA:

bis(O,N-trimethylsilyl)acetamide

Mtr:

4-methoxy-2,3,6-trimethylsulfonyl

PMA:

phorbol 12-myristate 13-acetate

MP:

myelopeptides

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Authors and Affiliations

  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    L. A. Fonina, M. A. Efremov, A. A. Mikhailova & E. A. Kirilina

  2. Institute of Experimental Cardiology, Russian Cardiological Research and Production Association, Russian Agency of Public Health and Social Development, Tret’ya Cherepkovskaya ul. 15a, Moscow, 121552, Russia

    E. V. Kudryavtseva & Zh. D. Bespalova

Authors
  1. L. A. Fonina
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  2. E. V. Kudryavtseva
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  3. Zh. D. Bespalova
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  4. M. A. Efremov
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  5. A. A. Mikhailova
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  6. E. A. Kirilina
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Corresponding author

Correspondence to E. A. Kirilina.

Additional information

Original Russian Text © L.A. Fonina, E.V. Kudryavtseva, Zh.D. Bespalova, M.A. Efremov, A.A. Mikhailova, E. A. Kirilina, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 4, pp. 493–497.

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Fonina, L.A., Kudryavtseva, E.V., Bespalova, Z.D. et al. Synthesis and properties of myelopeptides possessing differentiating activity. Russ J Bioorg Chem 36, 456–460 (2010). https://doi.org/10.1134/S1068162010040035

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  • DOI: https://doi.org/10.1134/S1068162010040035

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