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Oxidation of dermatan sulfate with a NaOCl-NaBr-2,2,6,6-tetramethylpiperidine-1-oxyl reagent in an aqueous medium

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Abstract

The oxidation of primary hydroxyl groups in dermatan sulfate with the NaOCl-NaBr-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) reagent in an aqueous alkaline medium was carried out for the first time. Modified dermatan sulfates containing hydrated aldehyde (15–50%) and carboxyl (25–100%) groups were obtained.

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Abbreviations

DS:

dermatan sulfate

IdoA:

iduronic acid

TEMPO:

2,2,6,6-tetramethylpiperidine-1-oxyl

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Authors and Affiliations

  1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, pr. Oktyabrya 141, Ufa, 450075, Russia

    I. Yu. Ponedel’kina, E. A. Khaibrahmanova, V. N. Odinokov, L. M. Khalilov & U. M. Dzhemilev

Authors
  1. I. Yu. Ponedel’kina
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  2. E. A. Khaibrahmanova
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  3. V. N. Odinokov
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  4. L. M. Khalilov
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  5. U. M. Dzhemilev
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Corresponding author

Correspondence to I. Yu. Ponedel’kina.

Additional information

Original Russian Text © I.Yu. Ponedel’kina, E.A. Khaibrahmanova, V.N. Odinokov, L.M. Khalilov, U.M. Dzhemilev, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 3, pp. 387–391.

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Ponedel’kina, I.Y., Khaibrahmanova, E.A., Odinokov, V.N. et al. Oxidation of dermatan sulfate with a NaOCl-NaBr-2,2,6,6-tetramethylpiperidine-1-oxyl reagent in an aqueous medium. Russ J Bioorg Chem 36, 354–358 (2010). https://doi.org/10.1134/S1068162010030106

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  • DOI: https://doi.org/10.1134/S1068162010030106

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