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The structure and mechanism of the action of type-IB DNA topoisomerases

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Abstract

DNA topoisomerases responsible for the superspiralization of genomic DNA participate in almost all vitally important cell processes, including replication, transcription, and recombination, and are essential for normal cell functioning. The present review summarizes published data for type-IB topoisomerases. The results concerning the thermodynamic, structural, and kinetic aspects of the functioning of topoisomerases and the peculiarities of the mechanisms of their action have been analyzed for the first time.

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Abbreviations

AA:

amino acid

dsDNA, ssDNA, and scDNA:

double-stranded, single-stranded, and supercoiled DNA

RSA:

roentgen structural analysis

topo:

DNA topoisomerase type I

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, pr. Lavrent’eva 8, Novisibirsk, 630090, Russia

    D. V. Bugreev & G. A. Nevinsky

  2. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    G. A. Nevinsky

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Original Russian Text © D.V. Bugreev, G.A. Nevinsky, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 3, pp. 293–311.

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Bugreev, D.V., Nevinsky, G.A. The structure and mechanism of the action of type-IB DNA topoisomerases. Russ J Bioorg Chem 36, 269–286 (2010). https://doi.org/10.1134/S1068162010030015

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