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The synthesis of O-substituted 3-oximes of 6α -methyl-16α,17α-cyclohexanopregn-4-ene-3,20-diones tritium-labeled in the 1,2-position

Abstract

1,2-Tritium-labeled 3-(O-carboxypropyl)- and 3-(O-carbomethoxypropyl)-oximes of 6α-methyl-16α,17α-cyclohexanopregn-4-ene-3,20-diones were obtained by the homogeneous catalytic hydrogenation of 1,2-dehydroprecursors with gaseous tritium and the subsequent separation of the resulting mixtures by HPLC. The specific radioactivities of 50–55 Ci/mmol were prepared using tris-(triphenylphosphine)-rhodium chloride.

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Abbreviations

UT:

uterine pentaranophilin

PR:

progesterone receptor

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Correspondence to V. P. Shevchenko.

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Original Russian Text © V.P. Shevchenko, I.Yu. Nagaev, I.S. Levina, L.E. Kulikova, N.F. Myasoedov, A.V. Kamernitzky, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 2, pp. 283–288.

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Shevchenko, V.P., Nagaev, I.Y., Levina, I.S. et al. The synthesis of O-substituted 3-oximes of 6α -methyl-16α,17α-cyclohexanopregn-4-ene-3,20-diones tritium-labeled in the 1,2-position. Russ J Bioorg Chem 36, 263–268 (2010). https://doi.org/10.1134/S1068162010020172

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  • DOI: https://doi.org/10.1134/S1068162010020172

Key words

  • pentaranes
  • synthesis
  • steroids
  • oxime
  • tritium
  • HPLC