Abstract
The usability of a new class of photo acids, namely, sulfonium hexaphosphates based on thioxanthenone, for the removal of the dimethoxytrityl protective group in the process of oligonucleotide synthesis has been studied in order to search for new detritylating agents for microarray oligodeoxyribonucleotide synthesis. 2,4-Diethyl-9-oxo-10-(4-heptyloxyphenyl)-9H-thioxanthenium hexafluorophosphate has been successfully used for the solid-phase synthesis of (dT)10.
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Original Russian Text © A.N. Sinyakov, A.A. Ryabinin, G.A. Maksakova, V.V. Shelkovnikov, V.A. Loskutov, E.V. Vasil’ev, N.V. Shekleina, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 1, pp. 139–141.
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Sinyakov, A.N., Ryabinin, A.A., Maksakova, G.A. et al. Sulfonium derivatives of thioxanthenone, a new class of photodetritylating agents for microarray oligonucleotide synthesis. Russ J Bioorg Chem 36, 130–132 (2010). https://doi.org/10.1134/S1068162010010152
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DOI: https://doi.org/10.1134/S1068162010010152