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Endogenous hypometabolic-hypothermic factors and their possible application to life in the cold

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Abstract

Mammalian hibernation is a natural model of tolerance of oragnisms, its tissues and cells to hypometabolism, hypothermia, hypoxia, bradycardia, and long-term hypophagia. Here, we review recent advances in the isolation and identification of some natural endogenous regulators from hibernating and cold-adapted animals: proteins, peptides, and nonpeptide substances. We also discuss the employment of molecular, biochemical, and physiological mechanisms of natural hypobiosis in ecology, cryomedicine, and the cryopreservation of genetic material from rare and endangered species. We suppose that our approaches can be extensively used (i) in medicine, when there is a need to slow down or suspend life processes for a short time; (ii) for the adaptation of humans to the cold; and (iii) in long-term space flights.

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Abbreviations

HIT:

hibernation induction trigger

HHFs:

hypometabolic-hypotermic factors

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142292, Russia

    L. I. Kramarova

  2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    R. Kh. Ziganshin

  3. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia

    E. N. Gakhova

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  1. L. I. Kramarova
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  2. R. Kh. Ziganshin
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  3. E. N. Gakhova
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Correspondence to L. I. Kramarova.

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Original Russian Text © L.I. Kramarova, R.Kh. Ziganshin, E.N. Gakhova, 2009, published in Bioorganicheskaya Khimiya, 2009, Vol. 35, No. 5, pp. 597–609.

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Kramarova, L.I., Ziganshin, R.K. & Gakhova, E.N. Endogenous hypometabolic-hypothermic factors and their possible application to life in the cold. Russ J Bioorg Chem 35, 538–548 (2009). https://doi.org/10.1134/S1068162009050021

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