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Apoptosis induced by granzyme B

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Abstract

Results of biochemical studies of apoptosis reactions induced by granzyme B are considered and summarized. Special attention is paid to the reactions of procaspase activation and limited proteolysis of apoptotic targets. Found values of kinetic constants of granzyme B-mediated enzymatic reactions are listed.

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Abbreviations

FasL:

ligand of Fas receptor

Hsp:

heat shock protein

IAP:

apoptosis inhibitor

ICAD:

inhibitor of nuclear nuclease CAD

NK cells:

natural killers

PARP-1:

poly(ADP-Rib) polymerase 1

Smac:

secondary mitochondrial caspase activator

TNF-α:

tumor necrosis fac tor α

TRAIL:

TNF-connected ligand inducing apoptosis

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Authors and Affiliations

  1. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia

    A. V. Sintsov & M. A. Khanin

  2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, Moscow, 117997, Russia

    E. I. Kovalenko

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Original Russian Text © A.V. Sintsov, E. I. Kovalenko, M.A. Khanin, 2008, published in Bioorganicheskaya Khimiya, 2008, Vol. 34, No. 6, pp. 725–733.

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Sintsov, A.V., Kovalenko, E.I. & Khanin, M.A. Apoptosis induced by granzyme B. Russ J Bioorg Chem 34, 647–654 (2008). https://doi.org/10.1134/S1068162008060010

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  • DOI: https://doi.org/10.1134/S1068162008060010

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